REPBASE--A DATABASE OF REPETITIVE SEQUENCES

描述：(摘自项目摘要)重复的DNA代表 超过50%的真核基因组，并包含大量的 关于基因组结构和进化的信息。它的知识是 对于理解两者之间的复杂关系至关重要 基因蓝图及其生物学功能。它也是 对基因组图谱和测序项目的实际意义。 不可避免的是，研究人员研究了越来越多的DNA序列 未来几年将不得不分析越来越多的重复 其中的元素以越来越多的细节融入其中。有在 这类研究至少有三个主要方面：(1)自动标注 使用已知重复序列的参考集合的重复DNA 和专门的计算机软件；(2)对特定重复的评价 基于现有的生物信息，以及(Iii)其他 涉及序列上下文和属性的专门研究 重复着。这样的研究将需要电子可用的和 不断更新的包含重复序列参考集合的数据库， 以浓缩形式组织的参考重复序列的描述，以及 专门的收藏品，允许详细研究可用的 同源重复。第一个重复DNA数据库被称为 《Repbase》已于1992年由我们组合发行。在这里，我们建议 进一步采取必要步骤改进和加强这一资源。我们的 具体目标包括： 1.开发和维护重复元素的参考文献集 从所有已测序的真核生物物种中。 2.发起一部同行评议的电子百科全书，其中包括，更新 关于重复DNA的关键信息。 3.发展和维护重复DNA的二级收集。

DESCRIPTION: (Taken from project abstract) Repetitive DNA represents over 50% of eukaryotic genomes and contains a tremendous wealth of information about genomic structure and evolution. Its knowledge is of crucial importance for understanding complex relationships between genetic blueprints and their biological functions. It is also of practical significance for genome mapping and sequencing projects. Inevitably, researchers studying growing numbers of DNA sequences in the coming years will have to analyze increasing numbers of repetitive elements integrated within them in ever growing detail. There are at least three major aspects of such studies: (I) automatic annotation of repetitive DNA using reference collections of sequences of known repeats and specialized computer software; (ii) evaluation of particular repeats based on the existing biological information, and (iii) other specialized studies involving sequence context and properties of the repeats. Such studies will require electronically available and constantly updated database containing reference collections of repeats, description of the reference repeats organized in a condensed form, and specialized collections allowing detailed studies of available homologous repeats. The first database of repetitive DNA known as "Repbase" has been released by our group in 1992. Here we propose further steps necessary to improve and enhance this resource. Our specific goals include: 1. Develop and maintain reference collections of repetitive elements from all sequenced eukaryotic species. 2. Initiate a peer-reviewed electronic encyclopedia containing, updated key information on repetitive DNA. 3. Develop and maintain secondary collections of repetitive DNA.