REPBASE UPDATE- A DATABASE OF REPETITIVE SEQUENCES

Repbase Update（www.girinst.org）是DNA序列的综合集合，目前代表来自所有真核生物物种的超过1200个家族和亚家族的重复元件。 每个家族都有一个独特的名字，参考出版的文献，并经常在简短的评论中描述。 在过去的两年里，数百个重复的家族被添加到Repbase更新中，这些家族要么在其他任何地方都没有报道，要么在它们的共有序列和生物学分类方面被彻底修订。我们的方法是基于计算机辅助的探索和分析公开可用的DNA序列数据。 Repbase Update已被世界各地的公共机构和私营公司常规用于常规基因发现，序列组装和探针设计。 此外，Repbase更新成为具有生物学和医学重要性的个人研究项目的独特资源。鉴于预期新的序列数据将大量涌现，我们建议继续开发、维护和电子传播这一资源。 特别是，我们希望发现和表征数百个新的重复家族，这些家族将继续在Repbase Update中以电子方式发布。 此外，我们将继续汇编和组织报告家庭的重复从所有真核生物物种。最后，我们将维护用于人类和啮齿动物重复序列自动注释的公共服务器，并生成哺乳动物基因组DNA中存在的重复元件的最新注释。 我们特别建议：1.继续开发、维护和电子分发所有已测序真核生物物种的重复元件参考集合。 2.生成存在于可用的哺乳动物基因组DNA序列中的重复元件的公共域图谱。

Repbase Update (http://www.girinst.org), is a comprehensive collection of DNA sequences, currently representing over 1200 families and subfamilies of repetitive elements from all eukaryotic species. Each family is identifiable by a unique name, referenced to published literature and often characterized in brief commentaries. Several hundreds of repetitive families added to Repbase Update during the last two years are either unreported anywhere else, or have been thoroughly revised in terms of their consensus sequences and biological classification. Our approach is based on computer-assisted exploration and analysis of publicly available DNA sequence data. Repbase Update has been routinely used by public institutions and private companies throughout the world in routine gene discovery, sequence assembly and probe design. In addition, Repbase Update became a unique resource for individual research projects of biological and medical importance. In light of the anticipated flood of new sequence data, we propose continuation of development, maintenance and electronic dissemination of this resource. In particular, we expect to discover and characterize hundreds of new repetitive families which will continue to be published electronically in Repbase Update. Furthermore, we will continue to compile and organize reported families of repeats from all eukaryotic species. Finally, we will maintain the public server for automatic annotation of human and rodent repeats and generate up-to-date annotation of repetitive elements present in genomic DNA of mammals. In particular we propose to: 1. Continue development, maintenance and electronic distribution of reference collections of repetitive elements from all sequenced eukaryotic species. 2. Generate public domain maps of repetitive elements present in available mammalian genomic DNA sequences.