Experimental coevolution in microbial communities

微生物群落的实验协同进化

• 批准号: NE/V012347/1
• 负责人: Angus Buckling
• 金额: $ 70.12万
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FV012347%2F1
• 关键词: Experimental; coevolution; microbial; communities

Coevolution is believed to be ubiquitous and have profound impacts on evolutionary and ecological processes. However, our understanding of coevolution is primarily derived from highly specialised pairwise interactions, such as hosts and parasites and plants and pollinators. Yet it is clear that species exist in complex communities, where they interact with multiple competing species. We currently have little idea as to how coevolution proceeds in these complex communities, or the resultant consequences of coevolution. We have developed a stable multi-species microbial system which we will use to experimentally determine how community diversity affects coevolution and its consequences, using a combination of phenotypic and 'omic techniques. We will test specific hypotheses generated from novel theory developed in parallel with the experimental work.

共同进化被认为是无处不在的，并对进化和生态过程产生深远影响。然而，我们对共同进化的理解主要来自高度专业化的成对相互作用，如寄主和寄生虫、植物和传粉者。然而，很明显，物种存在于复杂的群落中，在那里它们与多个相互竞争的物种相互作用。我们目前对共同进化如何在这些复杂的群落中进行，或者共同进化的结果是什么，知之甚少。我们已经开发了一个稳定的多物种微生物系统，我们将使用表型和组学技术相结合的方法，通过实验确定群落多样性如何影响共同进化及其后果。我们将测试与实验工作平行发展的新理论产生的特定假说。

项目成果

The three Ts of virulence evolution during zoonotic emergence.

• DOI: 10.1098/rspb.2021.0900
• 发表时间: 2021-08-11
• 期刊: Proceedings. Biological sciences
• 作者: Visher E;Evensen C;Guth S;Lai E;Norfolk M;Rozins C;Sokolov NA;Sui M;Boots M
• 通讯作者: Boots M

Copper selects for siderophore-mediated virulence in Pseudomonas aeruginosa.

• DOI: 10.1186/s12866-022-02720-w
• 发表时间: 2022-12-13
• 期刊: BMC MICROBIOLOGY
• 影响因子: 4.2
• 作者: Lear, Luke;Hesse, Elze;Buckling, Angus;Vos, Michiel
• 通讯作者: Vos, Michiel

Antagonistic Mobile Genetic Elements Can Counteract Each Other's Effects on Microbial Community Composition.

• DOI: 10.1128/mbio.00460-23
• 发表时间: 2023-04-25
• 期刊: MBIO
• 影响因子: 6.4
• 作者: Castledine, Meaghan;Newbury, Arthur;Lewis, Rai;Hacker, Christian;Meaden, Sean;Buckling, Angus
• 通讯作者: Buckling, Angus

Fitness effects of plasmids shape the structure of bacteria-plasmid interaction networks.

• DOI: 10.1073/pnas.2118361119
• 发表时间: 2022-05-31
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Newbury, Arthur;Dawson, Beth;Umper, Uli Kl;Hesse, Elze;Castledine, Meaghan;Fontaine, Colin;Buckling, Angus;Sanders, Dirk
• 通讯作者: Sanders, Dirk

Supplemental Materials for "The Three Ts of Virulence Evolution During Zoonotic Emergence" from The three Ts of virulence evolution during zoonotic emergence

“人畜共患病出现期间毒力进化的三个 T”的补充材料来自《人畜共患病出现期间毒力进化的三个 T》

• DOI: 10.6084/m9.figshare.15074120
• 发表时间: 2021
• 作者: Visher E