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EFFECT OF AGE ON PANCREATIC BETA CELL RESPONSE TO CHANGES IN INSULIN SENSITIVITY

EFFECT OF AGE ON PANCREATIC BETA CELL RESPONSE TO CHANGES IN INSULIN SENSITIVITY
年龄对胰腺β细胞对胰岛素敏感性变化反应的影响
批准号：
6274696
负责人：
JEFFREY B. HALTER
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274696
关键词：
age difference aging clinical research glucose tolerance human old age (65+) human subject insulin insulin sensitivity /resistance nicotinate pancreatic islets pharmacokinetics secretion young adult human (21-34)

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英文摘要
Human aging is associated with glucose intolerance and changes in insulin sensitivity but age effects on pancreatic beta cell function in humans are not clear. In healthy young people pancreatic beta cell function adapts to insulin resistance by increasing sensitivity to glucose resulting in increased insulin secretion. Insulin sensitivity can be changed by several pharmacological agents one of which is nicotinic acid which induces insulin resistance and enhances insulin secretion responses in healthy young adults. We propose to study insulin secretion responses of young and elderly subjects (with and without impaired glucose tolerance) before and after nicotinic acid administration to test the hypothesis that aging causes impaired pancreatic beta cell adaptation to insulin resistance.
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Summer Research Training in Aging for Medical Students
Summer Research Training in Aging for Medical Students
Summer Research Training in Aging for Medical Students
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