EFFECT OF FAT AND FIBER ON COLONIC INTESTINAL EPITHELIAL CELLS
EFFECT OF FAT AND FIBER ON COLONIC INTESTINAL EPITHELIAL CELLS
批准号:
6277100
负责人:
STEVEN J SHIFF
金额:
$5.84万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-12-01 至 1999-11-30
中文摘要
这项研究考察了不同水平的饮食脂肪和
英文摘要
This research examines the effect of different levels of dietary fat and
fiber on the proliferation and death of colonic epithelial cells.
Subjects are given a well-controlled diet (weight maintaining, metabolic),
with fat/fiber combination (high, normal or low fat and high, normal or
low fiber) as the independent variable. Upon admission, after baseline
endoscopic biopsy (by flexible sigmoidoscopy), subjects are placed on a
low fat, high fiber diet for 4 wks. Assessment of colonic epithelium,
sodium butyrate, and Ki-ras oncogene mutations are performed using
endoscopic biopsy, blood, and stool sample. SIGNIFICANCE OF STUDY: Colon
cancer is a common human malignancy. Dietary fat and fiber have been
shown to affect the incidence of colorectal cancer. Populations consuming
diets high in fat and low in fiber overall have greater incidence rates of
colorectal cancer, compared to populations consuming less fat and more
fiber. It is not entirely clear whether dietary fat and fiber are
independent variables with respect to colon carcinogenesis. Sodium
butyrate, a short chain fatty acid, is generated in the colon in large
quantities as dietary fiber is fermented by colonic bacteria. Sodium
butyrate, in vitro, reduces the proliferation and induces apoptosis in
cultured colon cancer cells. FUTURE PLANS: Once a sufficient subject
population is studied and laboratory and statistical analyses are
completed, we will be able to determine the effects of dietary fat and
fiber on several parameters in the colonic mucosa which might be important
indicators of colon cancer risk. Additional studies will focus on the
level of fat and fiber that produces the highest risk for colon cancer and
eventually to isolate those substances in this diet that are responsible
for predisposition to colon cancer.
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EFFECT OF PLANT PHENOLIC COMPOUNDS ON HUMAN COLON EPITHELIAL CELLS
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批准号:6277128
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项目类别:
-
资助金额:$5.84万
-
财政年份:1997
-
负责人:STEVEN J SHIFF
-
依托单位:
EFFECT OF FAT AND FIBER ON COLONIC INTESTINAL EPITHELIAL CELLS
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批准号:6246952
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项目类别:
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资助金额:$5.86万
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财政年份:1997
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负责人:STEVEN J SHIFF
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依托单位:
EFFECT OF DIETARY FAT ON COLONICAL EPITHELIAL CELLS
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批准号:6115891
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项目类别:
-
资助金额:$4.54万
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财政年份:1997
-
负责人:STEVEN J SHIFF
-
依托单位:
EFFECT OF PLANT PHENOLIC COMPOUNDS ON HUMAN COLON EPITHELIAL CELLS
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批准号:6115894
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项目类别:
-
资助金额:$4.54万
-
财政年份:1997
-
负责人:STEVEN J SHIFF
-
依托单位:
EFFECT OF FAT AND FIBER ON COLONIC INTESTINAL EPITHELIAL CELLS
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批准号:6115866
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项目类别:
-
资助金额:$4.54万
-
财政年份:1997
-
负责人:STEVEN J SHIFF
-
依托单位:
EFFECT OF DIETARY FAT ON COLONICAL EPITHELIAL CELLS
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批准号:6277125
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项目类别:
-
资助金额:$5.84万
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财政年份:1997
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负责人:STEVEN J SHIFF
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依托单位:
DIETARY PLANT PHENOLICS--EFFECT ON COLONIC BIOMARKERS
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批准号:2748909
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项目类别:
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资助金额:$39.79万
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财政年份:1996
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负责人:STEVEN J SHIFF
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依托单位:
DIETARY PLANT PHENOLICS--EFFECT ON COLONIC BIOMARKERS
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批准号:2458301
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项目类别:
-
资助金额:$33.66万
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财政年份:1996
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负责人:STEVEN J SHIFF
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依托单位:
DIETARY PLANT PHENOLICS--EFFECT ON COLONIC BIOMARKERS
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批准号:2895825
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项目类别:
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资助金额:$23.14万
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财政年份:1996
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负责人:STEVEN J SHIFF
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依托单位:
DIETARY PLANT PHENOLICS--EFFECT ON COLONIC BIOMARKERS
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批准号:2011323
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项目类别:
-
资助金额:$38.41万
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财政年份:1996
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负责人:STEVEN J SHIFF
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依托单位:
DIETARY PLANT PHENOLICS--EFFECT ON COLONIC BIOMARKERS
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批准号:6573807
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项目类别:
-
资助金额:$16.02万
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财政年份:1996
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负责人:STEVEN J SHIFF
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依托单位:
EFFECT OF CAFFEINATED BEVERAGES ON COLONIC EPITHELIAL CELLS
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批准号:5219585
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:STEVEN J SHIFF
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依托单位:--
EFFECT OF CAFFEINATED BEVERAGES ON COLONIC EPITHELIAL CELLS
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批准号:3741607
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:STEVEN J SHIFF
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依托单位:
海外基金