EFFECT OF PLANT PHENOLIC COMPOUNDS ON HUMAN COLON EPITHELIAL CELLS

植物酚类化合物对人结肠上皮细胞的影响

• 批准号: 6277128
• 负责人: STEVEN J SHIFF
• 金额: $ 5.84万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277128
• 关键词: catechols; chemoprevention; clinical research; colon; colon neoplasms; drug screening /evaluation; eicosanoid metabolism; flavonoids; gastrointestinal epithelium; human subject; nonsteroidal antiinflammatory agent; phenols; plant extracts; quercetin

Nonsteroidal antiinflammatory drugs (NSAIDs) prevent the development of colorectal conver in the general population. Epidemiological studies have estimated that regular use of these compounds can reduce the mortality rate from colorectal cancer by as much as 50%. Despite the fact that these compounds are among the most widely used pharmaceuticals worldwide, the mechanisms by which these compunds prevent colon cancer is not fully understood. Epidemiological studies have also shown that consumption of a diet rich in fruits and vegetables reduces the incidence of and mortality from colorectal cancer. The exact chemical components contained in fruits and vegeatbles that possess these anti-cancer properties have not been identified. However, there are several compounds known to be abundant in commonly consumed fruits and vegetables---the plant phenolics such as curcumin, rutin, and quercetin---that have biological properties intriguingly similar to those of the NSAIDs. Therefore, the rationale for this study is to determine whether these plant phenolic compounds influence the epithelial cells of the colonic mucosa similar to sulindac, a classical NSAID chemopreventive agent. This study tests the hypothesis that the plant phenolic compounds: curcumin, quercetin, and rutin influence biomarkers of cell turnover and measurements of arachidonic acid (AA) metabolism in the epithelial cells of the mucosa of the human large intestine in vivo. In addition, it tests the postulate that the effect of these compunds on these parameters are similar to those of sulindac, a chemopreventive NSAID.

非甾体类抗炎药（NSAIDs）可预防 在一般人群中的结肠直肠癌。 流行病学研究 估计经常使用这些化合物可以降低死亡率 结直肠癌的发病率高达50%。 尽管事实上 这些化合物是全世界最广泛使用的药物， 这些化合物预防结肠癌的机制并不完全 明白流行病学研究还表明， 饮食中富含水果和蔬菜可降低发病率和死亡率 得了结肠直肠癌 水果中所含的确切化学成分 而具有这些抗癌特性的蔬菜 鉴定 然而，已知有几种化合物在 通常食用的水果和蔬菜-植物酚类物质， 姜黄素，芦丁和槲皮素---具有生物学特性 与NSAIDs相似。 因此， 这项研究是为了确定这些植物酚类化合物是否 影响结肠粘膜的上皮细胞类似于舒林酸， 一种典型的NSAID化学预防剂。这项研究验证了这一假设 植物酚类化合物姜黄素槲皮素和芦丁 影响细胞更新生物标志物和花生四烯酸的测量 (AA)人体大血管粘膜上皮细胞的代谢 体内肠。 此外，它还检验了假设，即 这些化合物对这些参数的影响与舒林酸相似， 化学预防性NSAID。