EFFECT OF DIETARY FAT ON COLONICAL EPITHELIAL CELLS

膳食脂肪对结肠上皮细胞的影响

• 批准号: 6277125
• 负责人: STEVEN J SHIFF
• 金额: $ 5.84万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277125
• 关键词: cancer risk; clinical research; colon; dietary excess; dietary lipid; gastrointestinal epithelium; human subject; intestinal mucosa; lipid metabolism; nutrient intake activity; nutrition related neoplasm /cancer; nutrition related tag; prostaglandins

Dietary fat has been associated with the pathogenesis of colorectal cancer in both epidemiologic and animal experimental studies. Both the amount and the type of fat consumed are important factors in this process. Many potential mechanisms for the effect of fat on the colonic mucosa have been proposed, but none have been proven. This study will determine the effect of short-term administration of a diet with a high proportion of several different fats on the turnover (the sum of cell duplication and cell death) of the colonic epithelial cells in human volunteers with different risk factors for colorectal cancer. In addition, the relationship between dietary fat intake and colonic mucosal production of various prostaglandins will be explored.

饮食脂肪与结直肠癌的发病机制有关 在流行病学和动物实验研究中。无论是金额还是 而摄入的脂肪类型是这一过程中的重要因素。许多 脂肪对结肠粘膜影响的潜在机制是 提议，但都没有得到证实。这项研究将确定其影响 短期服用几种高比例的饮食 不同脂肪对周转率(细胞复制和细胞总数)的影响 不同疾病患者结肠上皮细胞的死亡 结直肠癌的危险因素。此外，两国之间的关系 不同日粮脂肪摄入量与结肠粘膜产量的关系 将探索前列腺素。