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MELATONIN TREATMENT OF AGE RELATED INSOMNIA

MELATONIN TREATMENT OF AGE RELATED INSOMNIA
褪黑激素治疗与年龄相关的失眠
批准号：
6278137
负责人：
ROBERT L SACK
金额：
$2.86万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6278137
关键词：
aging alternative medicine attention circadian rhythms clinical research clinical trials hormone therapy human subject human therapy evaluation melatonin pharmacokinetics sleep disorders wakefulness

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中文摘要
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英文摘要
This protocol will test the hypnotic efficacy of low-dose (physiological replacement) melatonin for the treatment of age-related insomnia. Each subject will be treated for two-week blocks (in rotation) with placebo and three different melatonin dosing strategies that produce unique pharmacokinetic profiles. Response variables will include measures of sleep, daytime alertness, and circadian phase. On the last night of each treatment arm, subjects will be admitted for pharmacokineetic, temperature sleep & circadian phase assessment.
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