COCAINE SENSITIVE DOPAMINE TRANSPORTER SYNTHESIS

可卡因敏感多巴胺转运蛋白合成

• 批准号: 6277496
• 负责人: MICHAEL J KUHAR
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277496
• 关键词: Mammalia; Primates; animal tissue; biological products; mental disorders; nervous system; proteins; substance abuse related disorder

The dopamine transporter is a key target or "receptor" for cocaine that mediates its addicting properties. Therefore, understanding the factors which control the levels of dopamine transporter in brain is essential for understanding mechanisms of drug addiction. This project plans to develop a method to measure the synthesis rate and degradation rate of the dopamine transporter, and the serotonin transporter as well. The serotonin transporter is important because it is a target or receptor for antidepressant drugs. Substantial progress has been made in that the serotonin transporter turnover has been measured and its half-life is 3.4 days. We are in the process of determining the same factors for the dopamine transporter.

多巴胺转运体是可卡因的关键目标或“受体”