PROMOTER CHARACTERIZATION OF THE CART GENE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Expression of the CART gene is important for obesity, drug abuse and other physiologic functions. The goal of these experiments have been to examine how expression of the gene is regulated. This project also focuses the effects of CART peptides and their localization. In terms of function, it has been found that CART peptide inhibits the action of cocaine, produces abnormal EEG at high doses, and is involved in stress. It has also been shown that CART peptides are in enteric ganglia. Importantly, CART peptide receptor bidnig has been identified in primary cell cultuteres of rat nucleus accumbens.