DIETARY FIBER, PHYTOESTROGENS AND REPRODUCTIVE HORMONES

膳食纤维、植物雌激素和生殖激素

• 批准号: 6278270
• 负责人: JOANNE LOUISE SLAVIN
• 金额: $ 3.69万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278270
• 关键词: clinical research; clinical trials; dietary fiber; female; human subject; lignans; nutrient interaction; nutrition related tag; phytoestrogens; reproductive hormone; steroid hormone metabolism; wheat

The study will examine the interaction between dietary fiber and flax, a known source of lignan precursors, on urine and serum sex steroid metabolism and urinary lignan concentrations in premenopausal women. Twenty four women will be recruited in anticipation that twenty will finish. Subjects will consume the followign dietary treatments in a randomized order: 1. a control diet, low in dietary fiber and lignans 2. a wheat bran diet, high in dietary fiber and low in lignans 3. a flaxseed diet, low in dietary fiber and high in lignans, and 4. a wheat bran plus flaxseed diet, high in dietary fiber and lignans. Each diet will be consumed for two cycles with biological sample collections in the second menstrual cycle of each treatment.

这项研究将研究膳食纤维和亚麻之间的相互作用， 已知来源的木脂素前体，尿和血清性类固醇 代谢和尿木脂素浓度。 预计将招募24名女性， 说完 受试者将在一周内接受以下饮食治疗。 随机顺序： 1.控制饮食，低膳食纤维和木脂素 2.麦麸饮食，高膳食纤维，低木脂素 3.亚麻籽饮食，低膳食纤维和高木脂素，和 4.麦麸加亚麻籽的饮食，富含膳食纤维和木脂素。 每种饲料将与生物样品一起食用两个周期 在每次治疗的第二个月经周期收集。