DIETARY FATTY ACIDS--ROLE OF HORMONALLY MEDIATED CANCERS

膳食脂肪酸——激素介导的癌症的作用

• 批准号: 6278267
• 负责人: JOANNE LOUISE SLAVIN
• 金额: $ 3.69万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278267
• 关键词: breast neoplasms; clinical research; clinical trials; dietary lipid; female; hormone related neoplasm /cancer; human subject; nutrition related neoplasm /cancer; nutrition related tag; saturated fatty acids; soybeans; steroid hormone metabolism; unsaturated fatty acids

This study will enchance our understanding of the relationship between diet and breast cancer, especially as it relates to steroid hormone metabolism. The overall objective is to use a controlled feeding study to examine the effects of varying the type of fat, but not the amount of total fat, in the diet on steroid hormone metabolism in premenopausal women. In feeding study 1 (year 1), two diets, one high in saturated fat and the other high in polyunsatured fat, will be used. Another objective is to examine whether dietary soy may moderate the effect of dietary saturated fatty acids on hormone metabolism. In feeding study 2 (year 2), two diets, one high in saturated fat with no added soy and the other high in saturated fat with soy, will be used.

这项研究将加深我们对两国关系的理解 饮食与乳腺癌，特别是与类固醇激素有关的 新陈代谢。总体目标是使用受控喂养研究来 检查不同脂肪类型的影响，但不是脂肪的数量 绝经前饮食中总脂肪对类固醇激素代谢的影响 女人。在喂养研究1(第1年)中，两种饮食，一种高饱和脂肪 另一种富含多不饱和脂肪，将被使用。另一个目标 就是研究饮食大豆是否可以缓和饮食的影响 饱和脂肪酸对激素代谢的影响。在喂养研究2(第2年)中， 两种饮食，一种是高饱和脂肪，不添加大豆，另一种是高饱和脂肪 在饱和脂肪中加入大豆，将会被使用。