BETA CELL REST TO PREVENT PROGRESSIVE BETA CELL DESTRUCTION IN ICA

β 细胞休息以防止 ICA 中 β 细胞的进行性破坏

• 批准号: 6281391
• 负责人: RICHARD JACKSON
• 金额: $ 2.01万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281391
• 关键词: autoimmune disorder; chemoprevention; clinical research; clinical trials; endocrine disorder chemotherapy; endocrine pharmacology; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; insulin; insulin dependent diabetes mellitus; pancreatic islet function; prediabetic state

Randomized, controlled trial comparing 3 treatment arms to determine if parenteral insulin therapy is effective in preventing clinical diabetes. The initial intervention was a pilot study started in 1988, in which 5 subjects were treated with a combination of IV insulin for 5 days every 9 months (in the GCRC), combined with twice daily injections of low dose insulin during the intervening months. The results were significant when compared to 7 controls who declined treatment. The study continues to follow the subjects to assess the significance of the finding that this type of intervention could be effective in preventing clinical diabetes and the subsequent complications, and to determine any differences between the three groups. The anticipated benefit is to possibly delay or prevent the development of Insulin Dependent Diabetes (IDDM).

随机对照试验比较3个治疗组来确定是否