SYNCHROTRON CRYSTALLOGRAPHY OF RNA 3 TERMINAL PHOSPHATE CYCLASE

RNA 3 末端磷酸环化酶的同步加速器晶体学

• 批准号: 6120417
• 负责人: ALEX WLODAWER
• 金额: --
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6120417
• 关键词: biological products; biomedical resource; enzymes; spectrometry

RNA 3'-terminal phosphate cyclase catalyzes the ATP-dependent conversion of the 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. It is an essential enzyme and conserved across all kingdoms. Data were collected for a crystal of RNA 3' Phosphate cyclase soaked in the solution containing 10mM AMP. Data collection statistics: 97% completeness at 3 A resolution and the R-factor (20 A - 3A) is 5.7. Unfortunately, it does not appear that AMP was bound with detectable occupancy.

RNA 3'端磷酸环化酶催化atp依赖性