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PROGESTERONE RECEPTOR DNA BINDING COMPLEX DETERMINED BY MAD

PROGESTERONE RECEPTOR DNA BINDING COMPLEX DETERMINED BY MAD
MAD 测定的孕酮受体 DNA 结合复合物
批准号：
6281297
负责人：
FRAYDOON RASTINEJAD
金额：
$2.48万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-15 至 1999-08-14
来源：
https://reporter.nih.gov/project-details/6281297
关键词：
biological products biomedical resource proteins radiography structural biology

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中文摘要
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英文摘要
We have produced crystals of the progesterone receptor (PR) DNA-binding complex bound to a 28 bp. response element. The crystals diffracted poorly (approx 3.5 A) on the home source. To enhance the resolution and solve the structure we used the tunable beamline at CHESS in conjuction with Se-Met containing crystals. In the first attempt to collect data, a limited data set was obtained at better than 3 angstrom resolution at two wavelengths. We are presently in the midst of obtaining a full MAD dataset for solving the structure.
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Identification of Hypoxia-Inducible Factor-2alpha Activators for Chronic Kidney Disease Anemia
  • 批准号：
    9906953
  • 项目类别：
  • 资助金额：
    $35.15万
  • 财政年份：
    2018
  • 负责人：
    FRAYDOON RASTINEJAD
  • 依托单位：
    UNIVERSITY OF OXFORD
Identification of Hypoxia-Inducible Factor-2alpha Activators for Chronic Kidney Disease Anemia
Structural Biology of Multi-Domain Nuclear Receptor Complexes
Molecular Characterization of Mammalian bHLH-PAS Transcription Factors
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