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TWO PHOTON IMAGING OF ALA INDUCED PPIX IN NORMAL & CANCER CELLS & TISSUES

TWO PHOTON IMAGING OF ALA INDUCED PPIX IN NORMAL & CANCER CELLS & TISSUES
正常情况下 ALA 诱导的 PPIX 的两次光子成像
批准号：
6121908
负责人：
MICHAEL G NICHOLS
金额：
$0.11万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-30 至 1999-08-31
来源：
https://reporter.nih.gov/project-details/6121908
关键词：
animal tissue bioengineering /biomedical engineering biomedical resource human tissue lasers skin technology /technique

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英文摘要
Our goals are to acquire simultaneous two-photon images of ALA-induced PpIX and NADH autofluorescence using several well-defined cell lines and normal and tumor tissues of the balb-c mouse. While much is known regarding the heme biosynthesis pathway, recent steady-state fluorescence polarization studies indicate the possibility that the site of PpIX formation may differ in normal and tumor tissues. We propose to address this issue using multiphoton excited NADH autofluorescence and possibly other extrinsic mitochondrial indicators to observe the localization of ALA-induced PpIX in the samples cited above.
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