DIAGNOSIS OF ATHEROSCLEROSIS IN MUSCULAR ARTERIES USING NIR RAMAN SPECTROSCOPY

这项研究的目的是证明拉曼光谱可以 用来评价人体的脂肪和钙盐含量 外周动脉。我们研究了167个颈动脉和股骨节段 动脉壁处于各种病理状态。来自的拉曼光谱 这些样本可以被准确地建模。由此产生的化学物质 将浓度与胆固醇和 用组织学方法测定钙矿物 经验丰富的心血管病理学家。两者之间存在着很强的相关性 光谱测量和形态发现是 验证了该方法在实际应用中的适用性 外周动脉。拉曼光谱可以提供可靠的 关于外周和冠状动脉的组织化学信息 动脉。这类信息可能有助于识别患有 在症状出现前容易破裂的斑块，允许 积极和定向的干预。对化学的准确认识 病变的CAL成分也可能有助于选择最 适当的治疗方式。

The objective of this study is to show that Raman spectroscopy can be used to evaluate the lipid and calcium salt contents of human peripheral arteries. We studied 167 segments of carotid and femoral artery wall in various pathological states. The Raman spectra from these samples could be accurately modeled. The resulting chemical concentrations were compared with the amounts of cholesterol and calcium mineral determined by histological evaluation by an experienced cardiovascular pathologist. Strong correlations between the spectroscopic measurements and the morphological findings were demonstrated, thus validating the applicability of the method to peripheral arteries. Raman spectroscopy can provide reliable histochemical information about peripheral, as well as coronary arteries. Such information may help identify individuals with rupture-prone plaques before the onset of symptoms, allowing aggressive and directed intervention. Accurate knowledge of the chemi cal composition of a lesion may also be useful in selecting the most appropriate treatment modality.