DIAGNOSIS OF ATHEROSCLEROSIS IN MUSCULAR ARTERIES USING NIR RAMAN SPECTROSCOPY
DIAGNOSIS OF ATHEROSCLEROSIS IN MUSCULAR ARTERIES USING NIR RAMAN SPECTROSCOPY
批准号:
6281785
负责人:
JUHAS SELENIUS
金额:
$0.38万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-06-01 至 1999-05-31
中文摘要
这项研究的目的是表明,拉曼光谱可以
用于评价人体脂质和钙盐含量
外周动脉 我们研究了167个颈动脉和股动脉节段
各种病理状态的动脉壁。 用拉曼光谱分析了
这些样本可以被精确地建模。 所得化学
将浓度与胆固醇的量进行比较,
通过组织学评价测定的钙矿物质
经验丰富的心血管病理学家。 之间有很强的相关性
光谱测量和形态学发现,
证明,从而验证了该方法的适用性,
外周动脉 拉曼光谱可以提供可靠的
外周和冠状动脉组织化学信息
动脉 这些信息可能有助于识别个人
在症状出现之前,容易破裂的斑块,
积极和有针对性的干预。 准确掌握化学知识
病变的成分也可能有助于选择最
适当的治疗方式。
英文摘要
The objective of this study is to show that Raman spectroscopy can
be used to evaluate the lipid and calcium salt contents of human
peripheral arteries. We studied 167 segments of carotid and femoral
artery wall in various pathological states. The Raman spectra from
these samples could be accurately modeled. The resulting chemical
concentrations were compared with the amounts of cholesterol and
calcium mineral determined by histological evaluation by an
experienced cardiovascular pathologist. Strong correlations between
the spectroscopic measurements and the morphological findings were
demonstrated, thus validating the applicability of the method to
peripheral arteries. Raman spectroscopy can provide reliable
histochemical information about peripheral, as well as coronary
arteries. Such information may help identify individuals with
rupture-prone plaques before the onset of symptoms, allowing
aggressive and directed intervention. Accurate knowledge of the chemi
cal composition of a lesion may also be useful in selecting the most
appropriate treatment modality.
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DIAGNOSIS OF ATHEROSCLEROSIS IN MUSCULAR ARTERIES USING NIR RAMAN SPECTROSCOPY
-
批准号:6615287
-
项目类别:
-
资助金额:$18.0万
-
财政年份:2002
-
负责人:JUHAS SELENIUS
-
依托单位:
DIAGNOSIS OF ATHEROSCLEROSIS IN MUSCULAR ARTERIES USING NIR RAMAN SPECTROSCOPY
-
批准号:6314196
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项目类别:
-
资助金额:$1.38万
-
财政年份:2000
-
负责人:JUHAS SELENIUS
-
依托单位:
DIAGNOSIS OF ATHEROSCLEROSIS IN MUSCULAR ARTERIES USING NIR RAMAN SPECTROSCOPY
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批准号:6121244
-
项目类别:
-
资助金额:$0.41万
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财政年份:1999
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负责人:JUHAS SELENIUS
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依托单位:
海外基金