DIAGNOSIS OF ATHEROSCLEROSIS IN MUSCULAR ARTERIES USING NIR RAMAN SPECTROSCOPY

使用近红外拉曼光谱诊断肌动脉粥样硬化

• 批准号: 6314196
• 负责人: JUHAS SELENIUS
• 金额: $ 1.38万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314196
• 关键词: biomedical resource; human tissue; musculoskeletal system; sexually transmitted diseases; technology /technique

The objective of this study is to show that Raman spectroscopy can be used to evaluate the lipid and calcium salt contents of human peripheral arteries. We studied 167 segments of carotid and femoral artery wall in various pathological states. The Raman spectra from these samples could be accurately modeled. The resulting chemical concentrations were compared with the amounts of cholesterol and calcium mineral determined by histological evaluation by an experienced cardiovascular pathologist. Strong correlations between the spectroscopic measurements and the morphological findings were demonstrated, thus validating the applicability of the method to peripheral arteries. Raman spectroscopy can provide reliable histochemical information about peripheral, as well as coronary arteries. Such information may help identify individuals with rupture-prone plaques before the onset of symptoms, allowing aggressive and directed intervention. Accurate knowledge of the chemi cal composition of a lesion may also be useful in selecting the most appropriate treatment modality.

这项研究的目的是表明，拉曼光谱可以 用于评价人体脂质和钙盐含量 外周动脉 我们研究了167个颈动脉和股动脉节段 各种病理状态的动脉壁。 用拉曼光谱分析了 这些样本可以被精确地建模。 所得化学 将浓度与胆固醇的量进行比较， 通过组织学评价测定的钙矿物质 经验丰富的心血管病理学家。 之间有很强的相关性 光谱测量和形态学发现， 证明，从而验证了该方法的适用性， 外周动脉 拉曼光谱可以提供可靠的 外周和冠状动脉组织化学信息 动脉 这些信息可能有助于识别个人 在症状出现之前，容易破裂的斑块， 积极和有针对性的干预。 准确的化学知识 病变的成分也可能有助于选择最 适当的治疗方式。