REFLECTANCE SPECTROSCOPY FOR DIAGNOSIS OF PRE CANCEROUS CHANGES IN COLON
REFLECTANCE SPECTROSCOPY FOR DIAGNOSIS OF PRE CANCEROUS CHANGES IN COLON
批准号:
6281757
负责人:
GEORGE ZONIOS
金额:
$1.51万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-06-01 至 1999-05-31
中文摘要
我们开发了一种新的基于光谱反射的方法
检测生物组织中与
癌症形成的早期阶段。我们使用了基于漫反射的设置
反射光谱仪在临床环境中收集数据
用于测量反射率数据的白光激励由
紧凑型4J/脉冲氙弧灯(EG&G,FX-249型)。那盏灯
提供10毫秒的脉冲宽度。激励光束被耦合到一个
200 fm芯径光纤(0.22 nA)。通过使用PULSE
白光光源的激发和反射率的门控检测
信号时,照明源的背景信号被最小化。
数据采集由486笔记本微型计算机控制。这个
研究采用收集住院期间结肠反射光谱的方法
内窥镜检查程序并使用物理模型进行处理。这个
模型考虑了光在氧-和-存在时的传播
脱氧血红蛋白和分散在胶原纤维上。这项研究有
结果表明:(A)有可能测量
利用物理模型描述活体中的人结肠组织
组织漫反射,以及(B)测量的光学特性
可以与生化和形态组成相关联
这对疾病的检测很有用。
英文摘要
We developed a new spectroscopic reflectance-based method of
detecting alterations in biological tissues which are related to the
early stages of cancer formation. We used setup based on diffuse
reflectance spectrometer to collect data in the clinical settings The
white light excitation for measured reflectance data was provided by a
compact 4J/pulse xenon arc lamp (EG&G, model FX-249). The lamp
provides a pulse width of 10 ms. Excitation beam was coupled into a
200 fm core diameter optical fiber (0.22 NA). By using pulsed
excitation of white light source and gated detection of reflectance
signal, background signal from illumination source was minimized.
Data acquisition is controlled by a 486-notebook microcomputer. The
study employs collection of reflected spectra in colon during hospital
endoscopy procedures and processing them using physical model. The
model takes into account propagation of light in presence of oxy- and
de-oxy- hemoglobin and scattering on coll agen fibers. This study has
shown that: (a) it is possible to measure the optical properties of
human colon tissue in vivo by employing a physical model describing
tissue diffuse reflectance, and (b) the optical properties measured
can be correlated with the biochemical and morphological composition
of tissue, which can be useful for the detection of disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
REFLECTANCE SPECTROSCOPY FOR DIAGNOSIS OF PRE CANCEROUS CHANGES IN COLON
-
批准号:6615299
-
项目类别:
-
资助金额:$18.0万
-
财政年份:2002
-
负责人:GEORGE ZONIOS
-
依托单位:
REFLECTANCE SPECTROSCOPY FOR DIAGNOSIS OF PRE CANCEROUS CHANGES IN COLON
-
批准号:6314208
-
项目类别:
-
资助金额:$1.38万
-
财政年份:2000
-
负责人:GEORGE ZONIOS
-
依托单位:
REFLECTANCE SPECTROSCOPY FOR DIAGNOSIS OF PRE CANCEROUS CHANGES IN COLON
-
批准号:6121217
-
项目类别:
-
资助金额:$2.04万
-
财政年份:1999
-
负责人:GEORGE ZONIOS
-
依托单位:
REFLECTANCE SPECTROSCOPY FOR DIAGNOSIS OF PRECANCEROUS CHANGES IN COLON
-
批准号:6252330
-
项目类别:
-
资助金额:$2.35万
-
财政年份:1997
-
负责人:GEORGE ZONIOS
-
依托单位:
DEVELOPMENT OF "SMART" SPECTRAL PROBES & PHANTOM STUDIES
-
批准号:5224197
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:GEORGE ZONIOS
-
依托单位:--
NON INVASIVE "OPTICAL HISTOLOGY" OF MUCOSAL DYSPLASIA
-
批准号:5224198
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:GEORGE ZONIOS
-
依托单位:--
CLINICAL EEM STUDIES OF COLONIC MUCOSA
-
批准号:5224218
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:GEORGE ZONIOS
-
依托单位:--
RAMAN SPECTRAL PROBES W/ DEPTH RESOLVING CAPABILITY
-
批准号:5224202
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:GEORGE ZONIOS
-
依托单位:--
MONTE CARLO SIMULATION OF LIGHT DISTRIBUTION IN TISSUES
-
批准号:5224194
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:GEORGE ZONIOS
-
依托单位:--
海外基金