SOFTWARE DEVELOPMENT & DISTRIBUTION

已经开发了两个软件包并分发了Lysis 并适应。这两个软件包都不断扩展到 纳入核心项目#1、#2和#中开发的新方法 #5.Lysis是一个互动的模块化程序包 执行可用于线性和非线性的高级任务 时间序列分析，以及系统建模和仿真。最新的 版本6.2包括“主要动态模式”分析技术 和一类新的“人工神经网络”，两者都是在 核心项目#1。这些计划是独一无二的 值得注意的是，许多生物医学领域的数据分析能力 申请。此外，Volterra独特的裂解程序 将核估计转换为MatLab工具包，以便于 在同龄人社区中推广它们的使用。在过去 授予年，我们继续分发和支持第4版 适应。版本4包括：扩展的模型文件库，包含 重要的药代动力学和药效学模型；完全错误 ID；信息中极大似然估计的分析 用每个估计器选择模型的标准；扩展预测 统计和残差分析；用户自定义辅助参数 模型.自适应试验的部分优化的抽样时间表 设计；自动多学科参数估计。版本4 支持以下硬件/软件平台： PC/Windows 95/NT(Digital VisualFortran v5.0)；PC/Windows 3.1(DOS) (Microsoft PowerStation Fortran v1.0)；Sun/Solaris；VAX/OpenVMS； HP/HP-UX(可根据要求提供)。版本4的用户指南 包括使用自适应进行建模的教程介绍。此外，还有一个 提供广泛的模型库，其中包括超过35个 药动学和药动学/动力学模型。这些图书馆 《用户指南》中对型号进行了详细说明，其中许多型号 中包含的许多示例运行中所示 导游。

Two software packages have been developed and distributed LYSIS and ADAPT. Both software packages are continuously expanded to incorporate new methodologies developed in Core Projects #1, #2 and #5. LYSIS is an interactive modular software package of programs performing high-level tasks that can be used for linear and nonlinear time-series analysis, and system modeling and simulation. The latest Version 6.2 includes the "principal dynamic mode" analysis technique and a novel class of "artificial neural networks", both developed in Core Project #1. These programs are unique to LYSIS and enhance significantly the data analysis capabilities in many biomedical applications. In addition, the unique LYSIS programs of Volterra kernel estimation were converted into MatLab toolset in order to promote their broader use among the peer community. During the past grant year we have continued the distribution and support Release 4 of ADAPT. Release 4 includes: extensive Model File Library containing important pharmacokinetic and pharmacodynamic models; complete error analysis for the maximum likelihood estimator in ID; information criteria for model selection with each estimator; expanded predictive statistics and residual analysis; user defined secondary parameter models; partially optimized sample schedules for adaptive trial designs; automated multiple subject parameter estimation. Release 4 is supported for the following hardware/software platforms: PC/Windows 95/NT (Digital Visual Fortran v. 5.0); PC/Windows 3.1 (DOS) (Microsoft PowerStation Fortran v 1.0); SUN/Solaris; VAX/OpenVMS; HP/HP-UX (available upon request). The User's Guide for Release 4 includes a tutorial introduction to modeling with ADAPT. Also, an extensive Model Library is available that includes over 35 pharmacokinetic and pharmacokinetic/dynamic models. These library Models are fully documented in the User's Guide and many are illustrated in the numerous example runs contained in the User's Guide.