ENHANCING EFFECTIVENESS OF LIGHT THERAPY FOR INSOMNIA

增强光疗治疗失眠的效果

• 批准号: 6348796
• 负责人: HENRY C SAVAGE
• 金额: $ 32.82万
• 依托单位: APOLLO LIGHT SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2002-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6348796
• 关键词: aging; circadian rhythms; clinical research; home health care; human old age (65+); human subject; human therapy evaluation; lighting; phototherapy; quality of life; sleep disorders

The direct economic costs of insomnia in the United States exceeds $15 billion per year. Up to 50% of the population over 65 years suffers from chronic insomnia. The result is both compromised health and a reduction in the quality of life. The magnitude of the problem is underscored by the fact that approximately 40% of hypnotic medications are prescribed to individuals over 60 years of age, and the proportion of use increases with age. The features that make up age-related sleep disturbance are suggestive of a circadian rhythms involvement, and growing evidence suggests that timed exposure to bright light can be an effective treatment for this disorder. Yet, previous work makes it clear that bright light treatments could be more beneficially applied if greater attention is given to specific physiological and behavioral factors that intervene to limit efficacy. The current application seeks to take advantage of recent findings which suggest that a low-maintenance treatment strategy that controls judiciously an individual's exposure to light throughout the 24-hour day may be critical to making this promising non-drug approach more effective. Using a lab-based assessment and in-home treatment approach, we will examine the effects a home ambient light operating system (HALOS) on the sleep quality and waking function of a group of older subjects with sleep maintenance insomnia. Development and implementation of this safe, affordable and easy-to-use approach for the effective treatment of age-related sleep disturbance will make a significant positive impact on the quality of life of individuals suffering from the disorder, while reducing the substantial economic cost to our health care system associated with the treatment and consequences of age-related insomnia.

在美国，失眠症的直接经济成本每年超过150亿美元。 65岁以上的人口中，高达50%患有慢性失眠症。 其结果是健康受损和生活质量下降。 这个问题的严重性是由以下事实强调的：大约40%的催眠药物是开给60岁以上的人的，并且使用的比例随着年龄的增长而增加。 构成与年龄相关的睡眠障碍的特征暗示了昼夜节律的参与，越来越多的证据表明，定时暴露于强光下可以有效治疗这种疾病。然而，以前的工作清楚地表明，如果更多地关注干预限制疗效的特定生理和行为因素，那么明亮的光治疗可能会更有益。 本申请试图利用最近的发现，这些发现表明明智地控制个体在整个24小时内暴露于光的低维持治疗策略对于使这种有希望的非药物方法更有效可能是至关重要的。 使用基于实验室的评估和家庭治疗方法，我们将研究家庭环境光操作系统（HALOS）对一组患有睡眠维持性失眠的老年受试者的睡眠质量和唤醒功能的影响。 开发和实施这种安全，负担得起和易于使用的方法来有效治疗与年龄相关的睡眠障碍，将对患有这种疾病的个人的生活质量产生显着的积极影响，同时减少与年龄相关的失眠的治疗和后果相关的医疗保健系统的重大经济成本。