Ultraviolet Light Devices for Vitamin D

维生素 D 紫外线装置

• 批准号: 6690674
• 负责人: HENRY C SAVAGE
• 金额: $ 16.45万
• 依托单位: APOLLO LIGHT SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690674
• 关键词: 1,25 dihydroxycholecalciferol; aging; clinical research; high performance liquid chromatography; human old age (65+); human subject; human therapy evaluation; nursing homes; nutrition related tag; osteomalacia; osteoporosis; patient oriented research; phototherapy; solar radiation; technology /technique development; ultraviolet therapy; vitamin D deficiency

DESCRIPTION (provided by applicant): Vitamin D deficiency is now recognized as a significant health problem for middle-aged and older adults. Vitamin D deficiency exacerbates osteoporosis and causes the bone disease, osteomalacia. Vitamin D deficiency increases risk of skeletal fractures. It is well known that the ultraviolet B portion of the solar spectrum is responsible for the cutaneous production if vitamin D3. It has been estimated that approximately 90 to 95% of most people's vitamin D requirement comes from their casual exposure to sunlight. However, people above the age of 50 years do not get adequate exposure to sunlight placing them at risk for vitamin D deficiency. The goal of this program is to determine the feasibility of developing ultraviolet B light sources that can be used in a nursing home setting or in an individual home for promoting the cutaneous production of vitamin D3. This will be accomplished by using a whole body ultraviolet B light source and a portable partial body ultraviolet B home device unit. The goal will be to test the effect of exposure to varying doses of whole body and partial body ultraviolet B radiation from these prototype commercial devices to determine their effect on raising the blood level of vitamin D and 25-hydroxyvitamin D, the major circulating form of vitamin D that is used to determine the vitamin D status. This study addresses an issue crucial to the successful commercial development of ultraviolet B radiation sources that can be placed in nursing homes or in an individual home for the therapeutic purpose of producing vitamin D3.

描述（由申请人提供）：维生素D缺乏症现在被认为是中年和老年人的一个重要健康问题。维生素D缺乏会加剧骨质疏松症，并导致骨骼疾病，骨软化症。维生素D缺乏会增加骨折的风险。众所周知，太阳光谱的紫外线B部分是皮肤产生维生素D3的原因。据估计，大多数人的维生素D需求量中约有90%至95%来自他们偶然暴露在阳光下。然而，50岁以上的人没有得到足够的阳光照射，使他们面临维生素D缺乏的风险。该计划的目标是确定开发紫外线B光源的可行性，该光源可用于养老院或个人家庭，以促进维生素D3的皮肤产生。这将通过使用全身紫外线B光源和便携式部分身体紫外线B家庭设备单元来实现。目标是测试暴露于来自这些原型商业设备的不同剂量的全身和部分身体紫外线B辐射的影响，以确定它们对提高维生素D和25-羟基维生素D的血液水平的影响，维生素D的主要循环形式用于确定维生素D状态。这项研究解决了一个关键的问题，成功的商业发展的紫外线B辐射源，可以放置在疗养院或在个人家庭的治疗目的，生产维生素D3。