Blue LED Light Panel For Treatment of Winter Depression

蓝色 LED 灯板治疗冬季抑郁症

• 批准号: 6550556
• 负责人: HENRY C SAVAGE
• 金额: $ 10.98万
• 依托单位: APOLLO LIGHT SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550556
• 关键词: biomedical equipment development; circadian rhythms; clinical biomedical equipment; clinical research; clinical trials; human subject; human therapy evaluation; light intensity; melatonin; patient oriented research; phototherapy; placebos; seasonal affective disorder; visible light

DESCRIPTION (provided by applicant): Multiple studies have established that bright light therapy is effective in alleviating symptoms of winter depression (seasonal affective disorder, or SAD). Light units used for treating SAD in the past have generally emitted polychromatic white light of highly variable spectral properties. Although several studies have attempted to test the effectiveness of specific wavelengths of red, blue and green light for treatment of SAD, the devices used in those studies employed relatively broad bandwidths of light. With the technological advancements in light emitting diodes (LEDs), the production of new light treatment equipment with much narrower bandwidths of light is possible. A recently completed action spectrum demonstrated that 446-477 nm is the most potent wavelength range for regulating melatonin secretion. These results suggest that a novel opsin photopigment, separate from the four classical visual opsins, mediates the effects of light on melatonin and raises the possibility that light treatment for SAD may share a common photoreceptor system and therefore, a similar spectral sensitivity. The specific aims of this proposed study are to: 1) produce an LED panel light box which emits narrow band light stimuli with a 470 nm peak (30 nm half-peak bandwidth) for light treatment of SAD; 2) confirm safety of this device through a hazard analysis based on accepted federal and industrial guidelines, and 3) use this device to test the hypothesis that light stimuli concentrated in the 470 nm range is therapeutically effective in treating SAD. Therapeutic efficacy will be tested in a double-blind, randomized cross-over study design comparing a narrow band LED light source with a spectral peak at 470 nm (30 nm half-peak bandwidth) to a narrow band dim red light placebo control with peak emission at 700 nm. Demonstration of efficacy of relatively narrow bandwidth blue light will pave the way for future studies in which this spectral range may be further tested for SAD treatment and circadian rhythm dysfunctions in order to maximize therapeutic benefits with lower light intensities and therefore, fewer side effects.

描述（由申请人提供）：多项研究表明，强光疗法可有效缓解冬季抑郁症（季节性情感障碍，或SAD）的症状。过去用于治疗SAD的光单元通常发射光谱特性高度可变的多色白光。虽然有几项研究试图测试特定波长的红、蓝、绿光治疗SAD的有效性，但这些研究中使用的设备采用了相对较宽的光带宽。随着发光二极管（led）技术的进步，生产具有更窄光带宽的新型光处理设备是可能的。最近完成的作用谱表明，446-477 nm是调节褪黑激素分泌最有效的波长范围。这些结果表明，一种新的视蛋白光色素，与四种经典视蛋白分离，介导光对褪黑激素的影响，并提出了SAD的光治疗可能具有共同的光感受器系统，因此具有相似的光谱灵敏度的可能性。本研究的具体目的是：1)制造一种LED面板灯箱，该灯箱可发出470 nm峰（30 nm半峰带宽）的窄带光刺激，用于SAD的光治疗；2)通过基于公认的联邦和行业指南的危害分析来确认该设备的安全性，3)使用该设备测试集中在470 nm范围内的光刺激对治疗SAD有效的假设。治疗效果将通过双盲、随机交叉研究设计进行测试，将光谱峰值为470 nm （30 nm半峰带宽）的窄带LED光源与峰值为700 nm的窄带弱红光安慰剂对照进行比较。证明相对窄带宽蓝光的有效性将为未来的研究铺平道路，在未来的研究中，该光谱范围可能会进一步测试SAD治疗和昼夜节律功能障碍，以便以更低的光强度最大化治疗效果，从而减少副作用。