CORE--LABORATORY ANIMALS

老龄化和阿尔茨海默氏症研究中心实验室动物核心 作为促进、丰富和协调动物的共享资源 中心五个组成部分项目中四个的模型研究 求婚。在之前的赠款和项目期内，该核心具有 开发和维护有屏障的、无疾病的蜂群 常规、老年、超龄和终生(39个月以上)卡路里 受限的神经学建模的大鼠，以减少数据 为新的和正在进行的研究折衷动物变量。我们有 从所有实验菌落中消除感染性病原体，构建 并翻新了新的有障碍的住宅区，建立了更好的 饲养行为模型研究动物的环境条件 行为测试实验室毗邻动物收容所。 这一核心组件的一个具体目标是继续提供 屏障持续移植的专门维护，常规， 卡路里限制，6-羟基多巴胺造模，并与老年大鼠对照。核心将会 继续推动动物模型研究的各个方面，一如既往 制定并实施了。第二个具体目标是提供其他核心 为老龄中心调查人员提供的服务包括全面的毛收入和 实验动物的组织病理学评价、血清学 对持续病毒(尤其是细小病毒)进行记录的监测 支原体无病状态与实验室持续咨询 老年大鼠的动物遗传学、建模和自发性疾病评估。 第三个具体目标是维持和向中心调查人员提供 营养(热量)受限，30月龄以上的Fisher 344只大鼠。 在第四个具体目标中，核心主任将开发一个自动化的NW 数据库将包括、监测和跟踪所有实验动物 在所有项目中使用。所有项目动物都将唯一标识为 植入电子应答器微芯片。这个数据库将是 与所有中心调查人员联网并可访问。核心意志 协调项目内部和项目之间所有动物的使用，以便 最大限度地提高动物的使用效率，消除任何潜在的 不必要和多余的动物用途。

The Aging and Alzheimer's Research Center Laboratory Animal Core operates as a shared resource which facilitates, enriches and coordinates animal model studies for four of the five component projects in the Center proposal. This Core has, over previous grant and project periods, developed and maintained barrier-sustained, disease-free colonies of conventional, aged, ultra-aged and lifetime (more 39 months) caloric restricted, neurologically modeled rats in order to reduce data compromising animal variables for new and ongoing studies. We have eliminated infectious agents from all experimental colonies, constructed and renovated new barriered housing areas, established improved environmental conditions for housing behavioral modeled research animals with behavioral testing laboratories contiguous to animal housing rooms. One specific aim of this core component is to continue to provide specialized maintenance of barrier sustained transplant, conventional, caloric-restricted, 6-OHDA modeled and control aged rats. The core will continue to facilitate all aspects of animal model studies as previously developed and implemented. A second specific aim is to provide other core services to Aging Center investigators including comprehensive gross and histopathological evaluations of experimental animals, serological surveillance to document a continuing virus (especially parvovirus) and mycoplasma disease-free status and continuous consultation on laboratory animal genetics, modeling and spontaneous disease evaluations in aged rats. A third specific aim is to maintain and provide Center investigators with nutritionally (caloric) restricted, aged (more 30 months) Fisher 344 rats. In the fourth specific aim, the Core Director will develop a nw, automated data base which will include, monitor and track all experimental animals used in all projects. All project animals will be uniquely identified with implanted with electronic, transponder microchips. This database will be networked to and be accessible by all Center investigators. The Core will coordinate the use of all animals within and between projects in order to maximize the efficiency of animal use and eliminate any potential unnecessary and redundant animal use.