CORE--IMMUNODEFICIENT RODENT /LABORATORY ANIMAL FACILITY

核心--免疫缺陷啮齿动物/实验动物设施

• 批准号: 6504956
• 负责人: JAMES O STEVENS
• 金额: $ 6.18万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6504956
• 关键词: SCID mouse; animal colony; athymic mouse; biomedical facility; disease /disorder model; histopathology; immunodeficiency; laboratory mouse; laboratory rat; lung neoplasms; neoplasm /cancer transplantation; xenotransplantation

The overall objective of this SPORE Immunodeficient Rodent laboratory Animal Core is to facilitate preclinical research in human lung cancer through the use of orthotopic cancer cell and tissue transplants (xenografts) in animal models. This shared resource will provide purchase, production breeding of and maintenance for specific pathogen-free, barrier- sustained, conventional, and severe-combined-immunodeficient (SCID) mice and athymic nude rats and mice for use by SPORE investigators in research projects in this program. This CORE will also provide gross and histopathology services, transgenic animal services, cancer will inoculation transfers, and harvests and animal model preparations for all program investigators using animal models. This CORE will maintain production colonies of pneumocystis carinii-free athymic nude rats and SCID mice in order to provide the necessary pulmonary disease-free animals required for these lung cancer studies. Animal studies supported by this CORE are focused on the primary SPORE Program objective which is to decrease incidence and mortality from lung cancer by discovery of cellular and molecular events involved in the progression of lung cancer and the translation of these discoveries into clinical applications.

这个SPORE免疫缺陷啮齿动物实验室的总体目标是 Animal Core旨在促进人类肺癌的临床前研究 通过使用原位癌细胞和组织移植 （异种移植物）的动物模型。 这种共享资源将提供购买， 无特定病原、无障碍、 持续、常规和严重联合免疫缺陷（SCID）小鼠 以及供SPORE研究人员在研究中使用的无胸腺裸鼠和小鼠 这个项目中。 该核心还将提供毛额和 组织病理学服务，转基因动物服务，癌症将 接种转移、收获和动物模型制备， 使用动物模型进行研究。 该核心将保持 无卡氏肺孢子虫裸鼠和SCID的生产集落 小鼠，以提供必要的无肺病动物 这些肺癌研究所需要的。 动物实验支持这一点 CORE专注于SPORE计划的主要目标，即 通过发现细胞癌降低肺癌的发病率和死亡率 和分子事件参与肺癌的进展， 将这些发现转化为临床应用。