CORE--IMMUNODEFICIENT RODENT /LABORATORY ANIMAL FACILITY

这个孢子免疫缺陷啮齿动物实验室的总体目标是 动物核心是促进人类肺癌的临床前研究 通过使用原位癌细胞和组织移植 (异种移植)动物模型。该共享资源将提供购买， 无特定病原菌、无屏障细菌的生产、选育与维护 持续、常规和严重联合免疫缺陷(SCID)小鼠 无菌裸鼠和裸鼠，供孢子研究人员使用 此计划中的项目。这一核心还将提供毛收入和 组织病理学服务，转基因动物服务，癌症将 所有人的接种转移、收获和动物模型准备 使用动物模型的程序调查人员。这个核心将保持 无卡氏肺孢子虫裸鼠和SCID的生产菌落 为小鼠提供必要的无肺部疾病的动物 是这些肺癌研究所必需的。在此支持下的动物研究 核心重点放在孢子计划的主要目标上，即 通过发现细胞性肺癌来降低肺癌的发病率和死亡率 以及参与肺癌进展的分子事件和 将这些发现转化为临床应用。

The overall objective of this SPORE Immunodeficient Rodent laboratory Animal Core is to facilitate preclinical research in human lung cancer through the use of orthotopic cancer cell and tissue transplants (xenografts) in animal models. This shared resource will provide purchase, production breeding of and maintenance for specific pathogen-free, barrier- sustained, conventional, and severe-combined-immunodeficient (SCID) mice and athymic nude rats and mice for use by SPORE investigators in research projects in this program. This CORE will also provide gross and histopathology services, transgenic animal services, cancer will inoculation transfers, and harvests and animal model preparations for all program investigators using animal models. This CORE will maintain production colonies of pneumocystis carinii-free athymic nude rats and SCID mice in order to provide the necessary pulmonary disease-free animals required for these lung cancer studies. Animal studies supported by this CORE are focused on the primary SPORE Program objective which is to decrease incidence and mortality from lung cancer by discovery of cellular and molecular events involved in the progression of lung cancer and the translation of these discoveries into clinical applications.