DEVELOPMENT OF COGNITIVE ACTIVATION TASKS FOR FUNCTIONAL NEUROIMAGING

我们开发了多种任务来激活功能神经成像研究中感兴趣的区域。1. 我们正在开发一种用于事件相关功能磁共振成像的注意力和编码连续性能测试。虽然精神分裂症患者的行为缺陷已被广泛报道，但这一任务的神经基础尚未被阐明。2. 我们开发了一套精心匹配的语言流畅性任务，使用PET CBF方法检查精神分裂症患者的语义加工、思维障碍和神经生理学之间的关系。我们还将在功能磁共振成像中使用语义处理任务来确定语义空间畸变的生理伴随。3. 为了检验情景记忆的加工水平，我们设计了一系列识别记忆任务。我们还特别注意开发一种不涉及主动加工的控制任务，以便更好地观察海马的激活。-认知精神分裂症神经影像学-人类受试者：访谈，问卷调查或仅调查

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. We are developing a Continuous Performance Test of attention and encoding to be used in event related fMRI. While behavioral deficits have been widely reported in schizophrenic patients, the neural substrate of this task has yet to be elucidated. 2. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We arel also using a semantic processing task in fMRI to determine the physiologic concomitants of aberrations in semantic space. 3. To examine the levels of processing account of episodic memory we devised a series or recognition memory tasks. We also paid special attention to the development of a control task that would not involve active processing so as to better observe hippocampal activation. - cognition schizophrenia neuroimaging - Human Subjects: Interview, Questionaires, or Surveys Only