DEVELOPMENT OF COGNITIVE ACTIVATION TASKS FOR FUNCTIONAL NEUROIMAGING

功能神经影像认知激活任务的开发

• 批准号: 6290575
• 负责人: Daniel Martin Weinberger
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290575
• 关键词: brain imaging /visualization /scanning; brain mapping; brain metabolism; cerebellum; clinical research; cognition; frontal lobe /cortex; functional magnetic resonance imaging; human subject; memory; neural information processing; neuropsychological tests; positron emission tomography; schizophrenia; verbal behavior

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. We are developing a Continuous Performance Test of attention and encoding to be used in event related fMRI. While behavioral deficits have been widely reported in schizophrenic patients, the neural substrate of this task has yet to be elucidated. 2. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. We arel also using a semantic processing task in fMRI to determine the physiologic concomitants of aberrations in semantic space. 3. To examine the levels of processing account of episodic memory we devised a series or recognition memory tasks. We also paid special attention to the development of a control task that would not involve active processing so as to better observe hippocampal activation. - cognition schizophrenia neuroimaging - Human Subjects: Interview, Questionaires, or Surveys Only

我们已经开发了各种任务来激活功能性神经成像研究中的感兴趣区域。1.我们正在开发一个连续的性能测试的注意力和编码用于事件相关的功能磁共振成像。虽然精神分裂症患者的行为缺陷已被广泛报道，但这项任务的神经基质尚未阐明。2.我们开发了一组精心匹配的言语流畅性任务，使用PET CBF方法来检查精神分裂症中语义处理、思维障碍和神经生理学之间的关系。我们也使用功能磁共振成像中的语义加工任务来确定语义空间畸变的生理伴随物。3.本研究设计了一系列再认记忆任务，以考察情景记忆加工的水平。我们还特别注意了一个控制任务的发展，不会涉及主动处理，以便更好地观察海马激活。- 认知型精神分裂症神经影像学.人类受试者：仅访谈、问卷调查或调查