GENETIC BASIS OF CORTICAL MALFUNCTION IN SCHIZOPHRENIA
精神分裂症皮质功能障碍的遗传基础
基本信息
- 批准号:6290581
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The purpose of this project is to find genetic loci linked to the impairment in cortical function found in schizophrenia. The method to be used is the affected sibling pair paradigm. Abnormalities of cortical function appear to be core features of chronic schizophrenia. Cortical function of patients and their siblings will be quantified using functional MRI, MR Spectroscopy and neuropsychological testing. These methods will be entered into the linkage analysis. Carefully diagnosed probands will recruited from our existing in patient population of persons with chronic schizophrenia. Other probands are recruited through the media and the National Alliance for the Mentally Ill. Diagnosis of probands is established from previous psychiatric records and a structured diagnostic interview. Siblings likewise are evaluated with a structured interview. All subjects give a blood sample for genetic analysis. Evaluation of cortical function is done using functional MRI and neuropsychological testing. These procedures have been chosen because it is already known that persons with schizophrenia demonstrate some abnormality compared to normal controls. It is hypothesized that some of the siblings will show one or more abnormal traits on these tests, thus suggesting that they may be phenotypically similar to their ill sibling even though they do not evidence (at the time of testing) the full blown syndrome. This study and the method of genetic analysis is unique in that it does not use diagnosis as the identifying variable. This is important because we already know that the genetic contribution to vulnerability to schizophrenia is not large. The best current estimates put it at around 20 to 40%. - Schzophrenia, MRI, MR - Neither Human Subjects nor Human Tissues
这个项目的目的是寻找与精神分裂症中发现的皮层功能障碍相关的遗传位点。使用的方法是受影响的同胞对范例。皮质功能障碍是慢性精神分裂症的核心特征。将使用功能性MRI、MR光谱和神经心理学测试对患者及其兄弟姐妹的皮质功能进行量化。这些方法将被输入连锁分析。仔细诊断的先证者将从我们现有的慢性精神分裂症患者人群中招募。其他先证者是通过媒体和全国精神病联盟招募的。先证者的诊断是根据以前的精神病记录和结构化的诊断面谈建立的。同样,通过结构化面试对求职者进行评估。所有受试者提供血液样本进行遗传分析。皮质功能的评估是通过功能性MRI和神经心理学测试来完成的。之所以选择这些程序,是因为已经知道精神分裂症患者与正常对照组相比表现出一些异常。假设一些兄弟姐妹在这些测试中显示出一种或多种异常性状,因此表明他们可能与他们患病的兄弟姐妹在表型上相似,即使他们没有证据(在测试时)完全爆发的综合征。这项研究和遗传分析的方法是独特的,因为它不使用诊断作为识别变量。这一点很重要,因为我们已经知道,基因对精神分裂症易感性的贡献并不大。目前最好的估计是20%到40%左右。- Schzdella,MRI,MR -既不是人类受试者也不是人类组织
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Daniel Martin Weinberger其他文献
Daniel Martin Weinberger的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Daniel Martin Weinberger', 18)}}的其他基金
Forecasting pneumococcal serotype frequencies to develop adult-specific vaccines
预测肺炎球菌血清型频率以开发成人特异性疫苗
- 批准号:
9192404 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Forecasting pneumococcal serotype frequencies to develop adult-specific vaccines
预测肺炎球菌血清型频率以开发成人特异性疫苗
- 批准号:
9327867 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Forecasting pneumococcal serotype frequencies to develop adult-specific vaccines
预测肺炎球菌血清型频率以开发成人特异性疫苗
- 批准号:
9075526 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Development Of Cognitive Activation Tasks For Functional Neuroimaging
功能神经影像认知激活任务的开发
- 批准号:
7735129 - 财政年份:
- 资助金额:
-- - 项目类别:
Genetic Basis Of Cortical Malfunction In Schizophrenia
精神分裂症皮质功能障碍的遗传基础
- 批准号:
7136266 - 财政年份:
- 资助金额:
-- - 项目类别:
Genetic Basis Of Cortical Malfunction In Schizophrenia
精神分裂症皮质功能障碍的遗传基础
- 批准号:
7594525 - 财政年份:
- 资助金额:
-- - 项目类别:
相似海外基金
FAIRClinical: FAIR-ification of Supplementary Data to Support Clinical Research
FAIRClinical:补充数据的 FAIR 化以支持临床研究
- 批准号:
EP/Y036395/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
Optimizing integration of veterinary clinical research findings with human health systems to improve strategies for early detection and intervention
优化兽医临床研究结果与人类健康系统的整合,以改进早期检测和干预策略
- 批准号:
10764456 - 财政年份:2023
- 资助金额:
-- - 项目类别:
The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and WorkforceDevelopment
IDeA 州临床研究资源中心联盟:通过机会交流、有效营销和劳动力发展增加 IDeA 州的临床试验
- 批准号:
10715568 - 财政年份:2023
- 资助金额:
-- - 项目类别:
The Mayo Clinic NeuroNEXT Clinical Research Site
梅奥诊所 NeuroNEXT 临床研究网站
- 批准号:
10743328 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Addressing Underperformance in Clinical Trial Enrollments: Development of a Clinical Trial Toolkit and Expansion of the Clinical Research Footprint
解决临床试验注册表现不佳的问题:开发临床试验工具包并扩大临床研究足迹
- 批准号:
10638813 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Improving Multicultural Engagement in Clinical Research through Partnership with Federally Qualified Health Centers and Community Health Worker Programs
通过与联邦合格的健康中心和社区卫生工作者计划合作,改善临床研究中的多元文化参与
- 批准号:
10823828 - 财政年份:2023
- 资助金额:
-- - 项目类别:
The Minnesota TMD IMPACT Collaborative: Integrating Basic/Clinical Research Efforts and Training to Improve Clinical Care
明尼苏达州 TMD IMPACT 协作:整合基础/临床研究工作和培训以改善临床护理
- 批准号:
10828665 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Promoting a Culture Of Innovation, Mentorship, Diversity and Opportunity in NCI Sponsored Clinical Research: NCI Research Specialist (Clinician Scientist) Award Application of Janice M. Mehnert, M.D.
在 NCI 资助的临床研究中促进创新、指导、多样性和机会文化:Janice M. Mehnert 医学博士的 NCI 研究专家(临床科学家)奖申请
- 批准号:
10721095 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Clinical Research Center for REstoration of NEural-based Function in the Real World (RENEW)
现实世界神经功能恢复临床研究中心 (RENEW)
- 批准号:
10795328 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Mentoring Scientists for Careers in HIV Translational Clinical Research
指导科学家从事艾滋病毒转化临床研究
- 批准号:
10762827 - 财政年份:2023
- 资助金额:
-- - 项目类别: