Shape Memory Thin Film Actuated Endoluminal Microdevices

形状记忆薄膜驱动腔内微型器件

• 批准号: 6406923
• 负责人: A DAVID JOHNSON
• 金额: $ 5.74万
• 依托单位: TINI ALLOY COMPANY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2003-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6406923
• 关键词: alloys; biomaterial compatibility; biomedical equipment development; blood vessel prosthesis; cerebrovascular surgery; miniature biomedical equipment; nickel; surface coating; titanium

DESCRIPTION (provided by applicant): Treatment of stroke and intracranial aneurysms will benefit from technologies that enable access and deployment of implements into small arteries in the brain. Outcomes of vascular procedures cart be improved by employing miniature structures made of highly compliant metal to reinforce weakened vascular tissues and to isolate hemorrhage sites from the blood flow. Minimally invasive procedures using microcatheter-based techniques about will be enhanced by availability of these tools. Endovascular devices fabricated of titanium-nickel thin film will enable the use of stents, filters, snares, retrievers, and endolumninal reconstruction within blood vessels too small, too diseased, or too tortuous to be treated with existing technology. Highly flexible, durable, bioconipatible material created by vacuum sputter deposition will be formed into cones, cylinders, and other shapes, fenestrated using micromachining photolithography, and delivered by microcatheters to lesion sites where the shape-changing characteristics of these alloys will be exploited to repair, reinforce, and protect vascular tissues. The objective of this research program is to fabricate micro-devices for the treatment of aneurysms, test their thermo-mechanical properties, demonstrate their efficacy through testing in simulated blood vessels, and prepare for their use in animal tests and human clinical trials. PROPOSED COMMERCIAL APPLICATION: These novel medical devices will greatly benefit those patients with aneurysms in the intracranial circulation. There is an enormous worldwide market for minimally invasive therapeutic modalities; this should create great interest in catheter or endoscope based delivery platforms for medical prosthetic devices that can be deployed within the body and assume a predetermined and stable configuration.

描述（由申请人提供）：中风和颅内动脉瘤的治疗将受益于能够访问和部署 植入大脑的小动脉。血管手术的结果 通过采用由高度顺应性制成的微型结构来改进购物车 金属可加固脆弱的血管组织并隔离出血部位 来自血液的流动。使用基于微导管的微创手术 这些工具的可用性将增强相关技术。 由钛镍薄膜制成的血管内装置将使 使用支架、过滤器、圈套器、回收器和腔内重建 血管内太小、病变太大或太曲折而无法治疗 与现有技术。高度灵活、耐用、生物相容性材料 通过真空溅射沉积产生的材料将形成圆锥体、圆柱体和 其他形状，使用微加工光刻技术开窗，并交付 通过微导管到达病变部位，其形状变化特征 这些合金将用于修复、强化和保护血管 组织。 该研究计划的目标是制造用于 治疗动脉瘤，测试其热机械特性，证明 通过模拟血管测试其功效，并为 它们在动物试验和人体临床试验中的应用。 拟议的商业应用： 这些新型医疗设备将极大地造福那些患有颅内循环动脉瘤的患者。微创治疗方式在全球范围内有着巨大的市场；这应该会引起人们对基于导管或内窥镜的医疗假肢装置输送平台的极大兴趣，这些装置可以部署在体内并呈现预定且稳定的配置。