Shape Memory Thin Film Actuated Endoluminal Microdevices

形状记忆薄膜驱动腔内微型器件

• 批准号: 6614062
• 负责人: A DAVID JOHNSON
• 金额: $ 3.52万
• 依托单位: TINI ALLOY COMPANY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2003-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6614062
• 关键词: alloys; biomaterial compatibility; biomedical equipment development; blood vessel prosthesis; cerebrovascular surgery; miniature biomedical equipment; nickel; surface coating; titanium

DESCRIPTION (provided by applicant): Treatment of stroke and intracranial aneurysms will benefit from technologies that enable access and deployment of implements into small arteries in the brain. Outcomes of vascular procedures cart be improved by employing miniature structures made of highly compliant metal to reinforce weakened vascular tissues and to isolate hemorrhage sites from the blood flow. Minimally invasive procedures using microcatheter-based techniques about will be enhanced by availability of these tools. Endovascular devices fabricated of titanium-nickel thin film will enable the use of stents, filters, snares, retrievers, and endolumninal reconstruction within blood vessels too small, too diseased, or too tortuous to be treated with existing technology. Highly flexible, durable, bioconipatible material created by vacuum sputter deposition will be formed into cones, cylinders, and other shapes, fenestrated using micromachining photolithography, and delivered by microcatheters to lesion sites where the shape-changing characteristics of these alloys will be exploited to repair, reinforce, and protect vascular tissues. The objective of this research program is to fabricate micro-devices for the treatment of aneurysms, test their thermo-mechanical properties, demonstrate their efficacy through testing in simulated blood vessels, and prepare for their use in animal tests and human clinical trials. PROPOSED COMMERCIAL APPLICATION: These novel medical devices will greatly benefit those patients with aneurysms in the intracranial circulation. There is an enormous worldwide market for minimally invasive therapeutic modalities; this should create great interest in catheter or endoscope based delivery platforms for medical prosthetic devices that can be deployed within the body and assume a predetermined and stable configuration.

描述(申请人提供)：中风和颅内动脉瘤的治疗将受益于能够获得和部署 进入大脑中的细小动脉。血管手术的结果 可以通过使用高度顺应性的 金属强化虚弱的血管组织并隔离出血部位 从血液流动来看。以微导管为基础的微创手术 这些工具的可用性将增强关于的技术。 由钛镍薄膜制成的血管内装置将使 支架、滤器、陷阱、回收器和腔内重建术的应用 血管内的血管太小、太多病或太曲折而无法治疗 利用现有的技术。高度柔韧、耐用、生物相容性好的材料 由真空溅射沉积产生的，将形成锥形、圆柱形和 其他形状，使用微机械光刻技术开窗，并交付 通过微导管对病变部位的形态变化特征进行分析 这些合金将被用于修复、加固和保护血管。 纸巾。 这项研究计划的目标是制造用于 动脉瘤的治疗，测试它们的热机械性能，证明 通过在模拟血管中测试它们的有效性，并为 它们在动物试验和人体临床试验中的应用。 建议的商业应用： 这些新的医疗设备将极大地造福于那些患有颅内循环动脉瘤的患者。微创治疗方式在全球范围内有着巨大的市场；这应该会引起人们对基于导管或内窥镜的医疗假体设备输送平台的极大兴趣，这些平台可以部署在体内，并具有预定和稳定的配置。