ROLE OF PSEUDOEPHEDRINE ON PERENNIAL ALLERGIC RHINITIS & ASSOCIATED SLEEP

伪麻黄碱对常年性过敏性鼻炎的作用

• 批准号: 7951272
• 负责人: Timothy John Craig
• 金额: $ 2.91万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951272
• 关键词: Allergic rhinitis; Antihistamines; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Decongestants; Drowsiness; Fatigue; Funding; Grant; Institution; Nose; Perennial Allergic Rhinitis; Pseudoephedrine; Research; Research Personnel; Resources; Role; Sleep; Sleep Apnea Syndromes; Sleep disturbances; Source; United States National Institutes of Health; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of the main manifestations of allergic rhinitis is congestion. Nasal congestion can predispose to sleep apnea and microarousals. This sleep disturbance can result in daytime somnolence and fatigue. The use of pseudoephedrine may be effective at reducing congestion, but objectively and subjectively, studies are lacking that demonstrate if the reduction of congestion will result in improved sleep and reduce somnolence. The possibility exists that sleep may be disturbed by use of long acting decongestants. It is important to determine this due to a high use of long acting decongestants and antihistamines.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 过敏性鼻炎的主要表现之一是充血。鼻塞易导致睡眠呼吸暂停和微觉醒。这种睡眠障碍会导致白天昏昏欲睡和疲劳。使用伪麻黄碱可能在减少充血方面有效，但客观和主观上，缺乏研究证明减少充血是否会改善睡眠和减少嗜睡。长效减充血剂的使用可能会干扰睡眠。由于长效减充血剂和抗组胺药的大量使用，确定这一点很重要。