Dopamine, frontal-subcortical circuits and risk for schizophrenia

多巴胺、额叶皮质下回路和精神分裂症风险

• 批准号: nhmrc : 1050504
• 负责人: A/Pr Alexander Fornito
• 金额: $ 44.79万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dopamine-frontal-subcortical-risk-schizophrenia/112158
• 关键词: Dopamine; frontal; subcortical; circuits; risk

Schizophrenia is a debilitating mental disorder characterized by psychotic experiences and emotional and cognitive difficulties. This project will map how disruptions of specific brain circuits relate to risk for schizophrenia and use genetic modeling techniques to understand how dysregulation of a specific chemical in the brain, dopamine, might cause these changes. This work will have important implications for developing new, more targeted treatments.

精神分裂症是一种以精神病经历和情感及认知困难为特征的使人衰弱的精神障碍。该项目将绘制特定大脑回路的中断如何与精神分裂症的风险相关，并使用遗传建模技术来了解大脑中特定化学物质多巴胺的失调如何导致这些变化。这项工作将对开发新的、更有针对性的治疗方法产生重要影响。