Maps, models and modifiers of brain changes in psychosis

精神病大脑变化的地图、模型和修正

• 批准号: nhmrc : 1136192
• 负责人: A/Pr Alexander Fornito
• 金额: --
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/maps-models-modifiers-changes-psychosis/1318402
• 关键词: Maps; models; modifiers; brain; changes

Psychosis fundamentally alters one’s relationship with reality. Brain scans can map which parts of the brain are affected by psychosis, but they cannot identify the cellular processes that cause these changes. My fellowship aims to address this gap by integrating brain imaging with genetics and mathematical modelling to identify the brain circuits and molecules that impact risk for psychosis, and to develop targeted therapies to modify these dysfunctional circuits.

精神病从根本上改变了一个人与现实的关系。脑部扫描可以绘制出大脑的哪些部分受到精神病的影响，但它们无法识别导致这些变化的细胞过程。我的奖学金旨在通过将大脑成像与遗传学和数学建模相结合来解决这一差距，以确定影响精神病风险的大脑回路和分子，并开发有针对性的治疗方法来修改这些功能失调的回路。