ECHOCARDIOGRAPHY FOR THE STRONG HEART STUDY

在此期间，强心家庭研究的试点阶段已成功完成，31个三代大家庭的920名成员参加了研究。 这些人和大约2,900名强心研究的其他成员正在接受颈动脉超声检查、无创动脉压波形记录和计算机化心电图的评估，所有这些都由GCRC的CDMAS协调。进展报告和研究结果总结：最重要的新发现是：（1）美国印第安人颈动脉粥样硬化的患病率高于同龄的白色或黑人;（2）糖尿病导致动脉肥大和动脉粥样硬化;（3）Q-的延长心电图T间期和ST段压低的计算机技术测量预测心血管死亡独立于标准风险因素;（4）女性的左心室射血分数和其他心室功能指标低于男性;（5）左心室质量和主动脉大小具有很强的遗传性，与已知的刺激因素无关;（6）糖尿病对左心室舒张功能有不利影响，与所有已知的危险因素无关。

During this period the pilot phase of the Strong Heart Family Study has been completed successfully with enrollment of 920 members of 31 extended 3-generation families. These individuals and approximately 2,900 additional members of the Strong Heart Study are undergoing assessment by carotid ultrasonography, non-invasive arterial pressure waveform recording and computerized electrocardiography, all of which are coordinated by CDMAS of the GCRC. Progress report and summary of findings: The most important new findings are: (1) American Indians have a higher prevalence of carotid atherosclerosis than White or Black Americans of the same age; (2) Diabetes causes arterial hypertrophy and atherosclerosis; (3) Prolongation of the Q-T interval of the electrocardiogram and ST segment depression measured by computerized techniques predict cardiovascular death independently of standard risk factors; (4) Left ventricular ejection fraction and other measures of ventricular function are lower in women than in men; (5) Left ventricular mass and aortic size are strongly heritable, independent of recognized stimuli to their growth; (6) Diabetes adversely affects left ventricular diastolic function, independently of all recognized risk factors.