CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IV

描述(改编自申请人的摘要) 强心研究(SHS)是一项以人群为基础的纵向研究 13名美国人心血管疾病及其危险因素调查 3个地理区域(亚利桑那州、达科他州和俄克拉何马州)的印第安人社区。 迄今为止的数据显示，美国印第安人的心血管疾病发病率现在高于美国 平均水平，而且似乎还在增加。在SHS第一阶段考试中，1527人 从俄克拉何马州招募了年龄在45岁到74岁之间的合格部落成员，并 考察了和1991年之间的关系。第二和第三阶段的SHS是在#年进行的 分别在1993-1995年和1997-1999年重新审查原来的队列。 在第三阶段，还进行了一项非常成功的试点家庭研究，以 论证在美洲印第安人中进行心血管疾病基因研究的可行性。 俄克拉荷马州中心招募了309名原始队列的家庭成员 11个大家庭将开始研究糖尿病的遗传决定因素 心血管疾病及其危险因素。这项申请建议延期五年。 (第四阶段)SHS扩大家庭研究，继续发病率和 原始队列的死亡率监测。三个现场中心中的每一个 将再招募900名家庭成员参加 包含至少2名SHS队列成员。此外，试点研究家庭 在900名会员注册后，会员将被邀请参加后续考试 在每个中心。第四阶段的家庭研究检查将包括心脏和 颈动脉超声检查，血压，无创测量 动脉僵硬(眼压测量)，心电图，人体测量，病史， 行为评估(社会经济状况、饮食、吸烟、饮酒和 体力活动)、血液化学、血脂和DNA。的具体目标 第四阶段的研究是扩大家庭研究，以增加对 基因分析，以继续监测原始队列以确定 更多的CVD病例，以调查一些相关生物标志物的相关性 和心功能与心血管疾病的发展有关，并开始死亡 家庭成员的监控。 公共学院美国印第安人健康研究中心 俄克拉何马大学健康科学中心建议继续其 作为外地中心和联合国环境规划署参与第四阶段研究 协调中心。

DESCRIPTION (Adapted from the applicant's abstract) The Strong Heart Study (SHS) is a population-based longitudinal study to investigate cardiovascular disease (CVD) and its risk factors in 13 American Indian communities in 3 geographic areas (Arizona, the Dakotas, and Oklahoma). Data to date show CVD rates in American Indians are now higher than the US average and appear to be increasing. In the SHS Phase I examination, 1,527 eligible tribal members from Oklahoma aged 45 to 74 years were recruited and examined between 1989 and 1991. Phases II and III of SHS were performed in 1993-1995 and in 1997-1999, respectively, to re-examine the original cohort. In Phase III, a highly successful pilot family study was also conducted to demonstrate the feasibility of a genetic study of CVD in American Indians. The Oklahoma center recruited 309 family members of the original cohort from 11 large families to begin the investigation of the genetic determinants of CVD and its risk factors. This application proposes a five-year extension (Phase IV) of SHS to expand the family study and to continue morbidity and mortality surveillance of the original cohort. Each of the 3 field centers will recruit an additional 900 participants who are members of families containing at least 2 SHS cohort members. Furthermore, the pilot study family members will be invited to a follow-up exam after the 900 members are enrolled at each center. The Phase IV family study exams will include cardiac and carotid ultrasound exams, blood pressures, noninvasive measurements of arterial stiffness (tonometry), ECGs, anthropometry, medical history, behavioral assessments (socio-economic status, diet, smoking, alcohol, and physical activity), blood chemistries, lipids, and DNA. The specific aims of the Phase IV study are to expand the family study to increase the power for genetic analyses, to continue surveillance of the original cohort to ascertain more CVD cases, to investigate the association of some pertinent biomarkers and cardiac functions with the development of CVD, and to initiate mortality surveillance in the family members. The Center for American Indian Health Research at the College of Public Health, University of Oklahoma Health Sciences Center proposes to continue its participation in Phase IV of the study as a Field Center and as the Coordinating Center.