CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IV

描述（改编自申请人摘要） Strong Heart Study（SHS）是一项基于人群的纵向研究， 13例美国人心血管疾病及其危险因素调查 3个地理区域的印第安人社区（亚利桑那州、达科他州和俄克拉荷马州）。 迄今为止的数据显示，美国印第安人的心血管疾病发病率现在高于美国 平均水平并且似乎正在增加。 在SHS第一阶段考试中， 招募了来自俄克拉荷马州年龄在45至74岁之间的合格部落成员， 1989年至1991年期间， SHS的第二阶段和第三阶段在 分别于1993-1995年和1997-1999年进行，以重新审查最初的队列。 在第三阶段，还进行了一项非常成功的试点家庭研究， 证明了在美国印第安人中进行CVD遗传研究的可行性。 俄克拉荷马州中心从最初的队列中招募了309名家庭成员， 11个大家庭开始调查的遗传决定因素， CVD及其危险因素 这份申请建议延长五年 社会科学及人文科学研究（第四阶段），以扩大家庭研究，继续研究发病率， 原始队列的死亡率监测。 三个外勤中心 将额外招募900名家庭成员参加 包含至少2个SHS群组成员。 此外，试点研究家庭 在900名会员注册后，会员将被邀请参加后续考试 在每个中心。 IV期家庭研究检查将包括心脏和 颈动脉超声检查，血压，无创测量 动脉硬度（张力测定）、ECG、人体测量、病史， 行为评估（社会经济状况、饮食、吸烟、饮酒和 身体活动）、血液化学、脂质和DNA。 的具体目标 第四阶段研究是为了扩大家庭研究，以增加 遗传分析，继续监测原始队列，以确定 更多的CVD病例，以研究一些相关生物标志物的相关性 心血管疾病的发展和心脏功能，并开始死亡 家庭成员的监视。 公共学院美国印第安人健康研究中心 健康，俄克拉荷马州健康科学中心大学建议继续其 作为现场中心参与研究的第四阶段， 协调中心。

DESCRIPTION (Adapted from the applicant's abstract) The Strong Heart Study (SHS) is a population-based longitudinal study to investigate cardiovascular disease (CVD) and its risk factors in 13 American Indian communities in 3 geographic areas (Arizona, the Dakotas, and Oklahoma). Data to date show CVD rates in American Indians are now higher than the US average and appear to be increasing. In the SHS Phase I examination, 1,527 eligible tribal members from Oklahoma aged 45 to 74 years were recruited and examined between 1989 and 1991. Phases II and III of SHS were performed in 1993-1995 and in 1997-1999, respectively, to re-examine the original cohort. In Phase III, a highly successful pilot family study was also conducted to demonstrate the feasibility of a genetic study of CVD in American Indians. The Oklahoma center recruited 309 family members of the original cohort from 11 large families to begin the investigation of the genetic determinants of CVD and its risk factors. This application proposes a five-year extension (Phase IV) of SHS to expand the family study and to continue morbidity and mortality surveillance of the original cohort. Each of the 3 field centers will recruit an additional 900 participants who are members of families containing at least 2 SHS cohort members. Furthermore, the pilot study family members will be invited to a follow-up exam after the 900 members are enrolled at each center. The Phase IV family study exams will include cardiac and carotid ultrasound exams, blood pressures, noninvasive measurements of arterial stiffness (tonometry), ECGs, anthropometry, medical history, behavioral assessments (socio-economic status, diet, smoking, alcohol, and physical activity), blood chemistries, lipids, and DNA. The specific aims of the Phase IV study are to expand the family study to increase the power for genetic analyses, to continue surveillance of the original cohort to ascertain more CVD cases, to investigate the association of some pertinent biomarkers and cardiac functions with the development of CVD, and to initiate mortality surveillance in the family members. The Center for American Indian Health Research at the College of Public Health, University of Oklahoma Health Sciences Center proposes to continue its participation in Phase IV of the study as a Field Center and as the Coordinating Center.