CORE--NMR

分子核磁共振共享设施有以下目标：1。为UAB综合癌症中心的成员在其研究项目中提供仪器。2.通过服务和咨询为癌症中心成员提供核磁共振专业知识。在上一个资助期间，85.5%的设施使用是由癌症中心的教职员工。由这些教员在NMR设施进行的一些研究涉及调节钙调蛋白活性的肽的设计、用于放射性标记单克隆抗体的双功能螯合剂的设计、作为抗癌药物的核苷酸类似物的设计、干扰素-tau、神经氨酸酶、载脂蛋白片段的结构研究、蛋白聚糖的生物合成、类视色素的表征、糖基化对c-Myc的影响、使用RNA-DNA三链体的抗基因疗法，病毒支架蛋白的结构研究，以及对神经胶质瘤有效的神经毒素。该设施的核磁共振系统也正在升级，以便向该设施的用户提供最先进的能力。建议核磁共振设施继续支持这些研究项目。

The Molecular NMR Shared Facility has the following objectives: 1. To provide instrumentation for use by the members of the UAB Comprehensive cancer Center in their research programs. 2. To provide NMR expertise to the Cancer Center members through service and consultation. During the previous funding period, 85.5% of the Facility usage was by Cancer Center faculty members. Some of the investigations conducted by these faculty members at the NMR Facility involved work on the design of peptides that regulate calmodulin activity, design of bifunctional chelating agents for radiolabeling monoclonal antibodies, design of nucleotide analogs as anti-cancer drugs, structural investigations on interferon-tau, neuraminidase, apolipoprotein fragments, biosynthesis of proteoglycans, characterization of retinoids, effect of glycosylation on c- Myc, anti-gene therapy using RNA-DNA triplexes, structural studies of viral scaffolding proteins, and neurotoxins effective against glioma. The NMR systems at the Facility are also being upgraded to provide state-of- the-art capabilities to the users of the Facility. Continued support of these research projects by the NMR Facility is proposed.