CORE--NMR

描述：(申请人描述)分子核磁共振共享设备具有 以下目标：1.提供仪器，以供 UAB综合癌症中心的成员参加他们的研究计划；以及 2.通过服务和为癌症中心成员提供核磁共振专业知识 咨询。 在上一个供资期间，85.5%的设施使用率为 癌症中心教职员工。由这些机构进行的一些调查 核磁共振设施的教职员工参与了多肽的设计工作 调节钙调蛋白活性的双功能螯合剂的设计 放射性标记单抗，核苷类似物设计为 抗癌药物，干扰素-tau的结构研究 神经毒素与钠通道胞外结构域、抑制剂的研究 流感病毒神经氨酸酶，载脂蛋白片段，生物合成 蛋白多糖，类维甲酸的特性，糖基化对 C-Myc，使用RNA-DNA三联体的抗基因治疗，病毒结构研究 支架蛋白和神经毒素对脑胶质瘤有效。核磁共振 该设施的系统也在升级，以提供最先进的 向该设施的用户提供能力。继续支持这些项目 提出了核磁共振设施的研究项目。

Description: (Applicant's Description) The Molecular NMR Shared Facility has the following objectives: 1. To provide instrumentation for use by the members of the UAB Comprehensive cancer Center in their research programs; and 2. To provide NMR expertise to the Cancer Center members through service and consultation. During the previous funding period, 85.5 percent of the Facility usage was by Cancer Center faculty members. Some of the investigations conducted by these faculty members at the NMR Facility involved work on the design of peptides that regulate calmodulin activity, design of bifunctional chelating agents for radiolabeling monoclonal antibodies, design of nucleoside analogs as anticancer drugs, structural investigations on interferon-tau, structural studies on neurotoxins and sodium channel extracellular domains, inhibitors of influenza virus neuraminidase, apolipoprotein fragments, biosynthesis of proteoglycans, characterization of retinoids, effect of glycosylation on c-Myc, antigene therapy using RNA-DNA triplexes, structural studies of viral scaffolding proteins, and neurotoxins effective against glioma. The NMR systems at the Facility are also being upgraded to provide state-of-the-art capabilities to the users of the Facility. Continued support of these research projects by the NMR Facility is proposed.