SYNTHESIS OF PHTHALOCYANINES FOR TUMOR PHOTOTHERAPY

用于肿瘤光疗的酞菁的合成

• 批准号: 6300343
• 负责人: MALCOLM E KENNEY
• 金额: $ 16.77万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6300343
• 关键词: X ray crystallography; biophysics; chemical structure function; chemical synthesis; drug design /synthesis /production; neoplasm /cancer photoradiation therapy; photochemistry; photosensitizing agents; phthalocyanin; quantum chemistry

Phthalocyanines have much promise as photosensitizers for photodynamic therapy, a therapy applicable to cancer treatment. It is now apparent that several promising new types of phthalocyanine or phthalocyanine-like photosensitizers can be made. This has led to the present proposal. The goal of the first part of this proposal is to design, synthesize and characterize new photosensitizers for PDT that are particularly efficient or that can be easily bioeliminated. All the photosensitizers are or contain phthalocyanine or phthalocyanine-like macrocycles. The goal of the second part of the research is to obtain basic information as to the efficiency with which the new compounds transduce photoenergy into chemically reactive species that will initiate photodynamic damage. To achieve this objective a series of photophysical and photochemical studies will be done on the new compounds. These studies will be focused mainly on compounds which have modified phthalocyanine rings, since it is anticipated that the intrinsic photosensitizing capability of the phthalocyanine chromophore in them will vary in important ways from compound to compound.

酞菁类化合物作为光动力学的光敏剂具有很大的前景 治疗，适用于癌症治疗的治疗。现在很明显 几种有前途的新型酞菁或类酞菁 可以制备光敏剂。这导致了目前的提议。的 本提案第一部分的目标是设计、综合和 表征特别有效的用于PDT的新光敏剂 或者可以容易地被生物消除。所有的光敏剂都是或 含有酞菁或酞菁类大环。 的目标 研究的第二部分是获得基本信息， 新化合物将光能转化为 化学活性物质，将引发光动力学损伤。到 为了达到这一目的， 将对新化合物进行研究。这些研究将集中在 主要是具有改性酞菁环的化合物，因为它 可以预期的是， 它们中的酞菁发色团将以重要的方式变化， 复合到复合。