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PROGESTIN EFFECTS ON UTERINE HOMEOSTASIS AND ANGIOGENESIS

PROGESTIN EFFECTS ON UTERINE HOMEOSTASIS AND ANGIOGENESIS
孕激素对子宫稳态和血管生成的影响
批准号:
6305873
负责人:
CHARLES JOSEPH LOCKWOOD
金额:
$2.1万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-12-01 至 2000-11-30

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中文摘要
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英文摘要
Estrogens and progestins generate hemostatic factors which increase hemostasis in the endometrium. Long term exposure to progestins in long acting contraceptives such as DepoProvera or Norplant will downregulate estrogen and progestin receptors and thus reverse this hemostatic pattern. Blood and endometrial samples from control women, women taking long acting contraceptives and (pre and post initiation of contraceptives) will be obtained to identify steroid receptors and tissue mediators of homeostasis. Endometrial stroma and endothelial cells will be cultured in an attempt to mimic these conditions in vitro.
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Thrombin Effects on Decidual TLR Expression
  • 批准号:
    7714226
  • 项目类别:
  • 资助金额:
    $20.61万
  • 财政年份:
    2009
  • 负责人:
    CHARLES JOSEPH LOCKWOOD
  • 依托单位:
Tissue Factor and Emdometriosis
  • 批准号:
    7318129
  • 项目类别:
  • 资助金额:
    $28.84万
  • 财政年份:
    2007
  • 负责人:
    CHARLES JOSEPH LOCKWOOD
  • 依托单位:
THERAPIES FOR PROGESTIN CONTRACEPTIVE INDUCED BLEEDING
The Yale WRHR Career Development Center
  • 批准号:
    7795475
  • 项目类别:
  • 资助金额:
    $47.52万
  • 财政年份:
    2004
  • 负责人:
    CHARLES JOSEPH LOCKWOOD
  • 依托单位:
海外基金