EFFECT OF RHGH ON ENDURANCE AND CARDIOPULMONARY FUNCTION IN GH DEFICIENT ADULTS

RHGH 对 GH 缺乏成人的耐力和心肺功能的影响

• 批准号: 6305956
• 负责人: DAVID L KLEINBERG
• 金额: $ 2.1万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305956
• 关键词: adult human (21+); body composition; cardiovascular function; clinical research; drug screening /evaluation; echocardiography; exercise; hormone therapy; human subject; human therapy evaluation; insulinlike growth factor; physical fitness; pituitary dwarfism; recombinant proteins; respiratory function; somatotropin

The objectives are to determine the effects of long-term rhGH replacement on endurance, cardiopulmonary function and cardiac structure using echocardiography and treadmill exercise testing. DEXA body scans will be performed to assess muscle, fat mas, and bone densitometry. Outcomes will be correlated with GH and IGF-1 levels post replacement therapy.

目的是使用超声心动图和平板运动试验确定长期rhGH替代对耐力、心肺功能和心脏结构的影响。将进行DEXA全身扫描，以评估肌肉、脂肪质量和骨密度测定。 结果将与替代治疗后的GH和IGF-1水平相关。