PREVALENCE OF GROWTH HORMONE DEFICIENCY & RANGES OF IGF-1 IN NORMAL ELDERLY

生长激素缺乏症的患病率

• 批准号: 7378259
• 负责人: DAVID L KLEINBERG
• 金额: $ 0.42万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378259
• 关键词: PREVALENCE; GROWTH; HORMONE; DEFICIENCY; RANGES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Growth hormone is secreted by the pituitary gland and causes body growth during infancy, childhood, and adolescence. IGF-1 is a protein secreted by the liver in response to GH. IGF-1 mediates most of the actions of GH, so most physicians use IGF-1 as a marker for GH deficiency. This is a cross-sectional clinical study to determine the normal range for insulin growth factor-1 (IGF-1) in healthy individuals aged 50-90 and to determine whether low IGF-1 correlates with low growth hormone (GH) levels and establishes the diagnosis of GH deficiency in otherwise, healthy, elderly individuals. This project is being done in collaboration with the NYU Aging and Dementia Center.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。生长激素由脑下垂体分泌，在婴儿期、儿童期和青春期促进身体生长。IGF-1是肝脏对生长激素的反应而分泌的一种蛋白质。胰岛素样生长因子-1介导了生长激素的大部分作用，因此大多数医生使用胰岛素样生长因子-1作为生长激素缺乏的标志物。这是一项横断面临床研究，旨在确定50-90岁健康人胰岛素生长因子-1(IGF-1)的正常范围，并确定低IGF-1是否与低生长激素(GH)水平相关，并在其他健康的老年人中建立GH缺乏的诊断。这个项目是与纽约大学老龄化和痴呆症中心合作完成的。