PREVALENCE OF GROWTH HORMONE DEFICIENCY & RANGES OF IGF-1 IN NORMAL ELDERLY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Growth hormone is secreted by the pituitary gland and causes body growth during infancy, childhood, and adolescence. IGF-1 is a protein secreted by the liver in response to GH. IGF-1 mediates most of the actions of GH, so most physicians use IGF-1 as a marker for GH deficiency. This is a cross-sectional clinical study to determine the normal range for insulin growth factor-1 (IGF-1) in healthy individuals aged 50-90 and to determine whether low IGF-1 correlates with low growth hormone (GH) levels and establishes the diagnosis of GH deficiency in otherwise, healthy, elderly individuals. This project is being done in collaboration with the NYU Aging and Dementia Center.