课题基金 / 基金详情

INTRACELLULAR HOMOCYSTEINE & METHIONINE KINETICS IN HUMANS

INTRACELLULAR HOMOCYSTEINE & METHIONINE KINETICS IN HUMANS
细胞内同型半胱氨酸
批准号：
6306068
负责人：
Dwight E Matthews
金额：
$3.29万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6306068
关键词：
aminoacid metabolism bioimaging /biomedical imaging blood chemistry clinical research cystine diagnosis design /evaluation disulfide bond gas chromatography mass spectrometry homocysteine human subject hydrazines intracellular methionine method development pharmacokinetics reducing agents stable isotope diagnosis thiols

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英文摘要
Homocysteine has been established as an independent risk factor in cardiovascular disease, but the reason why some individuals have elevated plasma homocysteine concentrations is not thoroughly understood. Homocysteine is a sulfur containing amino acid that is a metabolic intermediate between the other sulfur containing amino acids,methionine and cysteine. Storch et al. developed a method using stable isotope tracers to evaluate sulfur amino acid kinetics.
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