IN VITRO ANTIVIRAL SCREEN FOR HERPESVIRUSES

疱疹病毒体外抗病毒筛查

• 批准号: 6409818
• 负责人: EARL R KERN
• 金额: $ 62.19万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6409818
• 关键词: Epstein Barr virus; Herpesviridae; antiviral agents; biomedical facility; cytomegalovirus; drug screening /evaluation; herpes simplex virus 1; herpes simplex virus 2; human herpesvirus 6; human herpesvirus 8; tissue /cell culture; varicella zoster virus

项目成果

Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3-fluorocyclopropylidene]methyl}-adenines and guanines.

抗巨细胞病毒剂环丙帕韦的氟类似物：(E)-和(Z)-9-{[2,2-双(羟甲基)-3-氟亚环丙基]甲基}-腺嘌呤和鸟嘌呤的合成和抗病毒活性。

• DOI: 10.1080/15257770701257210
• 发表时间: 2007
• 期刊: Nucleosides, nucleotides & nucleic acids
• 作者: Zhou,Shaoman;Zemlicka,Jiri;Kern,EarlR;Drach,JohnC
• 通讯作者: Drach,JohnC

Efficacy of methylenecyclopropane analogs of nucleosides against herpesvirus replication in vitro.

核苷亚甲基环丙烷类似物对体外疱疹病毒复制的功效。

• DOI: 10.1081/ncn-120026633
• 发表时间: 2003
• 期刊: Nucleosides, nucleotides & nucleic acids
• 作者: Kushner,NicoleL;Williams,StephanieL;Hartline,CarollB;Harden,EmmaA;Bidanset,DeborahJ;Chen,Xinchao;Zemlicka,Jiri;Kern,EarlR
• 通讯作者: Kern,EarlR

Synthesis of methylenecyclobutane analogues of nucleosides with axial chirality and their phosphoralaninates: a new pronucleotide effective against Epstein-Barr virus.

具有轴向手性的核苷亚甲基环丁烷类似物及其磷酸丙氨酸盐的合成：一种有效对抗 Epstein-Barr 病毒的新前核苷酸。

• DOI: 10.1177/095632020201300406
• 发表时间: 2002
• 期刊: Antiviral chemistry & chemotherapy
• 作者: Wang,Ruifang;Kern,EarlR;Zemlicka,Jiri
• 通讯作者: Zemlicka,Jiri

Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.

评估核苷膦酸酯及其类似物和前药抑制正痘病毒复制的作用。

• DOI: 10.1128/aac.47.7.2193-2198.2003
• 发表时间: 2003
• 期刊: Antimicrobial agents and chemotherapy
• 影响因子: 4.9
• 作者: Keith,KathyA;Hitchcock,MichaelJM;Lee,WilliamA;Holý,Antonin;Kern,EarlR
• 通讯作者: Kern,EarlR

Synthesis and biological activities of 2-functionalized purine nucleosides.

2-功能化嘌呤核苷的合成和生物活性。

• DOI: 10.1081/ncn-120019498
• 发表时间: 2003
• 期刊: Nucleosides, nucleotides & nucleic acids
• 作者: Nair,Vasu;Bera,Bindu;Kern,EarlR
• 通讯作者: Kern,EarlR