Optical Imaging Device of the Retinal Function

描述（由申请人提供）：视网膜电生理的光学成像装置， 在第一阶段开发和测试的一个功能（OID-RF）将用于成像30 人类实验对象本申请的目的是确定 通过光学显微镜检测神经纤维丢失的灵敏度和特异性 视网膜功能成像。OID-RE测量的是 由于氧合血红蛋白饱和度的变化而出现的视网膜 以响应活跃神经元的代谢需求。拟议的OlD-RF 利用最新的技术进步，在高灵敏度电荷耦合 器件（CCD）相机和多光谱成像。OID-RF提供了一个目标， 以功能图像的形式定位信息的定量方法 视网膜上神经元的活动。该项目将汇集， 测试和应用一种新的商用OID-RF。与此同时，第一阶段原型将 用于在爱荷华州大学进行广泛的人类受试者测试。 具体目的是记录OID-RF检测NFL的灵敏度。 20名因神经纤维缺失而诊断为视野丧失的患者将 成像并光学测量其NFL损伤。 拟议商业应用：不可用

DESCRIPTION (provided by applicant): An optical imaging device of the retinal function (OID-RF) developed and tested in Phase I will be used to image 30 human subjects. The objective of this application is to determine the sensitivity and specificity for detecting nerve fiber loss through optical imaging of retinal function. OID-RE measures the change in the reflectance of the retina that occurs as a result of the changes in oxyhemoglobin saturation in response to the metabolic demands of active neurons. The proposed OlD-RF exploits recent technological advances in high sensitivity charge coupled device (CCD) cameras and multispectral imaging. OID-RF provides an objective, quantitative means of localizing information in the form of a functional image of neuronal activity across the retina. The proposed project will assemble, test, and apply a new commercial OID-RF. In parallel the Phase I prototype will be used to embark on an extensive human subject test at the University of Iowa. The specific aims are to document the sensitivity of OID-RF for detecting NFL. 20 patients with diagnosed visual field loss due to the nerve fiber loss will be imaged and their NFL damage optically measured. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE