Adaptive Optics Fundus Imager

描述（由申请人提供）：在第一阶段，Kestrel公司开发并展示了一种视网膜成像系统，该系统将多光谱成像技术与自适应光学和图像去卷积相结合，以提供小于（<10微米）的高分辨率体内图像。Kestrel已经在人类和非人类测试对象上演示了Shack-Hartmann波前传感器、自适应光学和图像解卷积算法等使能技术。美国和西班牙的其他人已经开发出实验室使用的自适应光学系统，并实现了约4微米分辨率的视网膜图像。这些实验室设备为研究人员提供了研究视网膜最小结构的强大工具。不幸的是，这些系统都不适合临床使用，因为它们的1度小视场（FOV）比大尺寸（大于30平方英尺）和它们的复杂性大。我们的系统将FOV从1度增加到20度，并将这些技术打包，以便它们可以轻松地安装在标准眼底成像仪上。我们已经展示了几项专利技术，包括抖动激光，以克服 镜面反射并消除用于波前测量的多个Shack-Hartmann图像。为了降低系统的成本并降低复杂性，反卷积算法允许我们使用更简单的（17个元件）双压电晶片自适应光学镜。我们的第一阶段原型系统及其专利修改解决了限制自适应光学研究仪器使用的技术问题。 第二阶段的第一个目标是设计和开发商业原型。 本项目的第二个目的是通过全面的人类受试者研究，评估视网膜和视盘的高分辨率图像的临床价值，而不是研究意义。图像将由经验丰富的眼科医生进行评价。将通过让眼科医生比较标准眼底相机和高分辨率眼底成像仪（HRSFI）拍摄的图像来评价高分辨率眼底成像仪（HRSFI）的临床功能。双盲研究的统计学评价将量化在诊断疾病如促增殖性糖尿病视网膜病变、年龄相关性黄斑变性和青光眼中的价值。

DESCRIPTION (provided by applicant): In Phase I Kestrel Corporation developed and demonstrated a retinal imaging system that combines multispectral imaging techniques with adaptive optics and image deconvolution to provide high resolution less than (<10 micrometers), in-vivo images. The enabling technologies such as the Shack-Hartmann wavefront sensor, adaptive optics, and image deconvolution algorithm have been demonstrated by Kestrel on human and non-human test objects. Others in the US and Spain have developed adaptive optics system for laboratory use and have achieved about 4 micrometer resolution images of the retina. These laboratory devices have given researchers a powerful tool for studying the smallest structures of the retina. Unfortunately, none of these systems are suitable for clinical use because of their small field of view (FOV) of 1 degree, than large size (greater than 30 square feet), and their complexity. Our system increases the FOV from 1 degree to 20 degrees and packages the technologies so that they easily fit on a standard fundus imager. We have demonstrated several patented technologies, including a dithered laser to overcome specular reflections and eliminate multiple Shack-Hartmann images for wavefront measurements. To reduce cost of the system and to reduce the complexity, a deconvolution algorithm has allowed us to use a simpler (17 element) bimorph adaptive optics mirror. Our prototype Phase I system with its patented modifications has solved the technical issues that have limited the use of adaptive optics to research instruments. The first aim of Phase II is to design and develop a commercial prototype. The second aim of this project is to evaluate, through a comprehensive human subjects study, not the research significance, but the clinical value of high resolution images of the retina and optic disc. The images will be evaluated by experienced ophthalmologists. The clinical functionality of the high resolution spectral fundus imager (HRSFI) will be evaluated by having the ophthalmologists compare images taken with a standard fundus camera and the HRSFI. A statistical evaluation of the double-blinded study will quantitate the value in diagnosing diseases such as pro-proliferative diabetic retinopathy, age-related macular degeneration, and glaucoma.