Microvascular Functional Imaging System

描述(由申请人提供)： VisionQuest Biomedical和新墨西哥大学(UNM)健康科学中心组成了一个团队，实施和展示一种热光成像系统，用于检测和量化与周围神经病相关的神经元和微血管功能障碍。该团队将开发和测试微血管功能成像系统(MFIS)，这是一种可以很容易地在临床环境和远程筛查环境中采用的设备。据估计，全球有1.71亿人患有糖尿病，其中包括2400多万美国人。糖尿病患者面临一系列并发症的风险，包括心脏病、肾脏疾病(肾病)、眼部疾病(糖尿病视网膜病变)和周围神经病变(糖尿病足)。两百万糖尿病患者在他们的一生中会患上足部溃疡。足部溃疡是糖尿病患者截肢的主要原因，占85%。我们的MFIS设备旨在显示功能信号的差异将揭示周围神经病变的临床前指征。第一阶段有三个具体目标要完成。第一个目标是集成、校准和测试MFIS设备。第二个目标是利用MFIS进行一项临床研究，研究对象将在新墨西哥大学内分泌诊所招募。在第三个目标中，我们将使用先进的信号和图像处理技术，如独立分量分析(ICA)，从热和光谱视频中捕获的功能响应中提取低电平信号。我们的商业化战略是创造两种商业仪器：一种基于热成像，可用于临床环境中的周围神经病变诊断，第二种基于光谱成像的低成本设备用于筛查目的。 公共卫生相关性： 周围神经病变(糖尿病足)是糖尿病引起的一种并发症，导致糖尿病患者中82,000人截肢。15%的糖尿病患者会在一生中的某个时候接受截肢手术。在这个项目中，我们将开发和测试微血管功能成像系统(MFIS)，这是一种热光成像系统，用于检测和量化与周围神经病变相关的神经元和微血管功能障碍。

DESCRIPTION (provided by applicant): VisionQuest Biomedical and the University of New Mexico (UNM) Health Science Center have formed a team to implement and demonstrate a thermal-optical imaging system for detecting and quantifying neuronal and microvascular dysfunction associated with peripheral neuropathy. This team will develop and test the Microvascular1Functional Imaging System (MFIS), a device that can be easily adopted for both a clinical environment and a tele-screening setting. Diabetes afflicts an estimated 171 million people worldwide, including more than 24 million Americans. Diabetic patients are at risk for a wide array of complications including heart disease, kidney disease (nephropathy), ocular diseases (diabetic retinopathy), and peripheral neuropathy (diabetic foot). Two million diabetics will develop a foot ulcer during their lifetime. Foot ulcers are the main cause, 85 percent, of lower extremity amputation in patients with diabetes. Our MFIS device is aimed to show that differences in the functional signals will reveal pre- clinical indications of peripheral neuropathy. There are three specific aims to be accomplished in Phase I. The first aim is to integrate, calibrate and test the MFIS device. The second aim is to use the MFIS to conduct a clinical study using subjects to be recruited at the University of New Mexico Endocrinology Clinic. In the third aim we will use advanced signal and image processing techniques, such as Independent Component Analysis (ICA), to extract low-level signals resulting from the functional response captured in thermal and spectral videos. Our commercialization strategy is to create two commercial instruments: One based in thermal imaging that can be used in a clinical setting for diagnosis of peripheral neuropathy, and a second low-cost device based on spectral imaging for screening purposes. PUBLIC HEALTH RELEVANCE: Peripheral neuropathy (diabetic foot) is a complication arising from diabetes that causes 82,000 lower extremity amputations in diabetic patients. Fifteen percent of diabetics will undergo amputation sometime in their lives. In this project, we will develop and test the Microvascular Functional Imaging System (MFIS), a thermal-optical imaging system for detecting and quantifying neuronal and microvascular dysfunction associated with peripheral neuropathy.