OPTICAL IMAGING DEVICE OF THE RETINAL FUNCTION

将演示一种视网膜功能的光学成像设备(OID-RF)。OID-RF将测量视网膜反射率的变化，这是由于氧合血红蛋白饱和度的变化响应活跃神经元的代谢需求而发生的。建议的OID-RF利用了高灵敏度电荷耦合器件(CCD)相机和多光谱成像方面的最新技术进步。OID-RF是一种客观、定量和定位的信息，以功能图像的形式显示整个视网膜上的神经元活动。拟议的项目将组装、测试和应用OID-RF，并展示用于检测和测量青光眼研究和临床研究中视神经头(ONH)和神经纤维层(NFL)病理的视网膜功能可视化系统。其具体目的是展示使用光学波长的光谱成像来检测刺激依赖的视网膜活动的功能成像，为6名正常人和6只青光眼制作二维地图，并展示适合商业化的临床设备的路径。拟议的商业应用：需要一种实用的、高度敏感的和特定的设备来帮助检测青光眼和其他眼病造成的神经纤维丢失。这一需求是由这样一个事实驱动的，即积极的治疗可能会降低进一步视盘损伤的比率。今天的仪器缺乏灵敏度，需要高达30%或更多的光盘损失才能进行检测。Kestrel正在推出光学功能成像技术和方法的创新应用，这些技术和方法可以改善青光眼的诊断。

An optical imaging device of the retinal function (OID-RF) will be demonstrated. OID-RF will measure the change in the reflectance of the retinal that occurs as a result of the changes in oxyhemoglobin saturation in response to the metabolic demands of active neurons. The proposed OID-RF exploits recent technological advances in high sensitivity charge coupled device (CCD) cameras and multispectral imaging. OID-RF an objective, quantitative, and localizing information in the form of a functional image of neuronal activity across the retina. The proposed project would assemble, test, and apply a OID-RF and demonstrate a retinal functional visualization system for use in detecting and measuring pathologies of the optic nerve head (ONH) and nerve fiber layer (NFL) in the research and clinical study of glaucoma. The specific aims are to demonstrate functional imaging for detecting stimulus dependent retinal activity using spectral imaging in optical wavelengths, produce 2-D maps for 6 normal subjects and 6 glaucomatous eyes, and demonstrate a path for a clinical device suitable for commercialization. PROPOSED COMMERCIAL APPLICATIONS: A practical, highly sensitive, and specific device is needed to aid in the detection of nerve fiber loss due to glaucoma and other eye diseases. The need is driven by the fact that aggressive therapy can probably reduce the rate of further optic disc damage. Today's instruments lack sensitivity, requiring up to 30% or more loss of the optic disc for detection. Kestrel is introducing innovative applications of optical functional imaging technologies and methodologies that could improve the diagnosis of glaucoma.