OPTICAL IMAGING DEVICE OF THE RETINAL FUNCTION

将演示视网膜功能的光学成像设备（OID-RF）。OID-RF将测量视网膜反射率的变化，该变化是由于氧合血红蛋白饱和度响应于活跃神经元的代谢需求而发生的。拟议的OID-RF利用了高灵敏度电荷耦合器件（CCD）相机和多光谱成像的最新技术进步。OID-RF是一种客观、定量和定位的信息，其形式为视网膜上神经元活动的功能图像。拟议的项目将组装、测试和应用OID-RF，并展示视网膜功能可视化系统，用于在青光眼的研究和临床研究中检测和测量视神经乳头（ONH）和神经纤维层（NFL）的病理。具体目的是展示使用光学波长的光谱成像检测刺激依赖性视网膜活动的功能成像，为6名正常受试者和6只昏迷眼制作2-D图，并展示适合商业化的临床设备的路径。拟议的商业应用：需要一种实用、高灵敏度和特异性的设备来帮助检测由于青光眼和其他眼部疾病引起的神经纤维损失。这种需求是由积极的治疗可能会降低进一步的视盘损伤的发生率这一事实驱动的。今天的仪器缺乏灵敏度，需要高达30%或更多的视盘损失进行检测。Kestrel正在引入光学功能成像技术和方法的创新应用，可以改善青光眼的诊断。

An optical imaging device of the retinal function (OID-RF) will be demonstrated. OID-RF will measure the change in the reflectance of the retinal that occurs as a result of the changes in oxyhemoglobin saturation in response to the metabolic demands of active neurons. The proposed OID-RF exploits recent technological advances in high sensitivity charge coupled device (CCD) cameras and multispectral imaging. OID-RF an objective, quantitative, and localizing information in the form of a functional image of neuronal activity across the retina. The proposed project would assemble, test, and apply a OID-RF and demonstrate a retinal functional visualization system for use in detecting and measuring pathologies of the optic nerve head (ONH) and nerve fiber layer (NFL) in the research and clinical study of glaucoma. The specific aims are to demonstrate functional imaging for detecting stimulus dependent retinal activity using spectral imaging in optical wavelengths, produce 2-D maps for 6 normal subjects and 6 glaucomatous eyes, and demonstrate a path for a clinical device suitable for commercialization. PROPOSED COMMERCIAL APPLICATIONS: A practical, highly sensitive, and specific device is needed to aid in the detection of nerve fiber loss due to glaucoma and other eye diseases. The need is driven by the fact that aggressive therapy can probably reduce the rate of further optic disc damage. Today's instruments lack sensitivity, requiring up to 30% or more loss of the optic disc for detection. Kestrel is introducing innovative applications of optical functional imaging technologies and methodologies that could improve the diagnosis of glaucoma.