Acupuncture in Cardiovascular Disease

针灸治疗心血管疾病

• 批准号: 6359787
• 负责人: HOLLY R MIDDLEKAUFF
• 金额: $ 19.13万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359787
• 关键词: acupuncture /acupressure; afferent nerve; alternative medicine; autonomic nervous system; blood pressure; cardiovascular disorder; cardiovascular disorder therapy; endogenous opioid; heart failure; human subject; human therapy evaluation; neural inhibition; neuroregulation; patient oriented research; positron emission tomography; psychological stressor; stress; striated muscles; sympathetic nervous system; vasoconstriction

DESCRIPTION (provided by applicant): Acupuncture is used to lower blood pressure in patients with hypertension, and to relieve angina in patients with coronary artery disease. While the biological mechanisms of acupuncture analgesia have been studied intensely in animals and humans, the biological mechanisms for modulation of the cardiovascular system in humans remain largely unexplored. Acupuncture at traditional acupoints, and at nonacupoints, decreases the blood pressure response during mental stress in normal humans. This depressor effect cannot be fully explained by a decline in muscle sympathetic nerve activity (MSNA). Further, in humans with heart failure (HF) in whom MSNA is elevated, we have preliminary data that acupuncture significantly decreases the MSNA response during mental stress. The following hypotheses will be tested: 1) acupuncture, performed at traditional acupoints and non-acupoints in normal humans, stimulates skeletal muscle afferent neurons causing a release of endogenous opioids, which oppose sympathetic excitation and vasoconstriction in visceral vascular beds, such as the kidney; 2) in humans with HF in whom MSNA is elevated and renal vasoconstriction is the rule, acupuncture utilizes similar mechanisms as in normal humans to produce I exaggerated inhibition of MSNA and reflex renal vasoconstriction. Positron emission tomography and I microneurography will be utilized to answer the following questions in normal humans and patients with heart failure: 1. Is acupuncture attenuation of BP during mental stress mediated by a decrease in renal vasoconstriction? 2. Is acupuncture sympathoinhibitory? 3. Is acupuncture modulation of the autonomic nervous system during mediated by muscle afferents? 4. Is acupuncture modulation of the autonomic nervous system mediated by activation of endogenous opioids? Understanding the mechanisms of acupuncture modulation of the autonomic nervous system in humans may help clarify its role as a therapeutic modality in cardiovascular diseases, such as heart failure.

描述（由申请人提供）：针灸用于降低高血压患者的血压，并减轻患有心绞痛的患者 冠状动脉疾病。而针灸的生物学机制 镇痛已经在动物和人类中进行了深入研究，生物学 人类心血管系统调节的机制很大程度上仍然存在 未探索。传统穴位和非目标的针灸， 在正常人的精神压力期间降低血压反应。 这种抑郁症效应无法通过肌肉下降来充分解释 交感神经活动（MSNA）。此外，在心力衰竭（HF）的人类中 MSNA升高的人，我们有针灸的初步数据 在精神压力期间，MSNA反应大大降低。下列 假设将进行测试：1）针灸，在传统穴位上进行 和正常人中的非顾问，刺激骨骼肌肉传入神经元 引起内源性阿片类药物的释放，这反对同情激发 和内脏血管床的血管收缩，例如肾脏； 2）in MSNA升高的HF的人类，肾血管收缩是规则， 针灸利用与正常人相似的机制来产生I MSNA和反射肾血管收缩的抑制作用。正面 排放断层扫描和I微功能学将用于回答 在正常人和心力衰竭患者中以下问题： 1。是通过减少介导的精神压力期间BP的针灸衰减 在肾血管收缩？ 2。针​​灸是交感抑制性的吗？ 3。是对自主神经系统的针灸调节。 肌肉传入？ 4。是对自主神经系统的针灸调节 内源性阿片类药物的激活？ 了解自主神经的针灸调节机制 人类的系统可能有助于阐明其作为治疗方式的作用 心血管疾病，例如心力衰竭。