CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE

可乐定与心力衰竭的骨骼肌病

• 批准号: 8167118
• 负责人: HOLLY R MIDDLEKAUFF
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167118
• 关键词: Chronic; Clonidine; Computer Retrieval of Information on Scientific Projects Database; Exercise Tolerance; Funding; Grant; Heart failure; Institution; Mechanoreceptors; Muscle; Myopathy; Patients; Research; Research Personnel; Resources; Source; Sympatholytics; United States National Institutes of Health; improved; skeletal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1. To determine if chronic therapy with another sympatholytic therapy, clonidine, reverses the skeletal myopathy of HF, and increases exercise tolerance. 1.1 Is the chronic decrease in MSNA in HF patients treated with clonidine associated with a reversal of the skeletal myopathy? 1.2 What is the effect of the improved skeletal myopathy on the augmented muscle mechanoreceptor sensitivity in HF?

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 具体目的1。确定使用另一种交感神经治疗的慢性治疗，可乐定，可逆转HF的骨骼肌病，并增加运动耐受性。 1.1与骨骼肌病逆转有关的可乐定治疗的HF患者MSNA的慢性减少？ 1.2改善骨骼肌病对HF增强肌肉机械感受器灵敏度的影响是什么？