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CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE

CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE
可乐定与心力衰竭的骨骼肌病
批准号:
8167118
负责人:
HOLLY R MIDDLEKAUFF
金额:
$0.59万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-12-01 至 2010-11-30

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项目成果

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中文摘要
翻译
该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得主要资金, 因此可以在其他CRISP条目中表示。列出的机构是 中心,不一定是研究者的机构。 具体目标1。确定另一种交感神经阻滞疗法可乐定的慢性治疗是否能逆转HF的骨骼肌病变,并增加运动耐量。 1.1可乐定治疗心力衰竭患者MSNA的慢性降低是否与骨骼肌病变的逆转有关? 1.2改善的骨骼肌病对HF患者增强的肌肉机械感受器敏感性有什么影响?
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1. To determine if chronic therapy with another sympatholytic therapy, clonidine, reverses the skeletal myopathy of HF, and increases exercise tolerance. 1.1 Is the chronic decrease in MSNA in HF patients treated with clonidine associated with a reversal of the skeletal myopathy? 1.2 What is the effect of the improved skeletal myopathy on the augmented muscle mechanoreceptor sensitivity in HF?
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会议论文
CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE
THE EFFECT OF SMOKING ON THE PATTERN OF NEURAL SYMPATHETIC OUTFLOW IN PREMENOPAU
CARDIAC RESYNCHRONIZATION THERAPY AND THE SKELETAL MYOPATHY OF HEART FAILURE
THE EFFECT OF SMOKING ON THE PATTERN OF NEURAL SYMPATHETIC OUTFLOW IN PREMENOPAU
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