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CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE

CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE
可乐定与心力衰竭的骨骼肌病
批准号:
8167118
负责人:
HOLLY R MIDDLEKAUFF
金额:
$0.59万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-12-01 至 2010-11-30

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项目成果

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中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金, 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目的1.确定使用另一种交感神经治疗药物可乐定的慢性治疗是否能逆转心力衰竭的骨骼肌病,并提高运动耐量。 1.1接受可乐定治疗的心力衰竭患者的MSNA慢性降低是否与骨骼肌病的逆转有关? 1.2骨骼肌病的改善对心衰患者肌力感受器敏感性的增强有何影响?
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1. To determine if chronic therapy with another sympatholytic therapy, clonidine, reverses the skeletal myopathy of HF, and increases exercise tolerance. 1.1 Is the chronic decrease in MSNA in HF patients treated with clonidine associated with a reversal of the skeletal myopathy? 1.2 What is the effect of the improved skeletal myopathy on the augmented muscle mechanoreceptor sensitivity in HF?
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会议论文
CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE
THE EFFECT OF SMOKING ON THE PATTERN OF NEURAL SYMPATHETIC OUTFLOW IN PREMENOPAU
CARDIAC RESYNCHRONIZATION THERAPY AND THE SKELETAL MYOPATHY OF HEART FAILURE
THE EFFECT OF SMOKING ON THE PATTERN OF NEURAL SYMPATHETIC OUTFLOW IN PREMENOPAU
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